Literature DB >> 7809158

Thermodynamic procedure to synthesize heteropolymers that can renature to recognize a given target molecule.

V S Pande1, A Y Grosberg, T Tanaka.   

Abstract

We suggest a procedure to synthesize polymers with characteristics similar to those observed in globular proteins: renaturability and the existence of an "active site" capable of specifically recognizing a given target molecule. This procedure is investigated by computer simulation, which finds a yield of up to 65%. We believe that, in principle, this scheme can be realized in vitro. The applicability of this approach as a model of prebiotic synthesis in vivo is also discussed.

Entities:  

Mesh：

Substances：

Year:  1994        PMID： 7809158      PMCID： PMC45563          DOI： 10.1073/pnas.91.26.12976

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  3 in total

1.  Long-range correlations in nucleotide sequences.

Authors:  C K Peng; S V Buldyrev; A L Goldberger; S Havlin; F Sciortino; M Simons; H E Stanley
Journal:  Nature       Date:  1992-03-12       Impact factor: 49.962

2.  Nonrandomness in protein sequences: evidence for a physically driven stage of evolution?

Authors:  V S Pande; A Y Grosberg; T Tanaka
Journal:  Proc Natl Acad Sci U S A       Date:  1994-12-20       Impact factor: 11.205

3.  Engineering of stable and fast-folding sequences of model proteins.

Authors:  E I Shakhnovich; A M Gutin
Journal:  Proc Natl Acad Sci U S A       Date:  1993-08-01       Impact factor: 11.205
  3 in total
  19 in total

1.  Statistical mechanics of protein-like heteropolymers.

Authors:  R I Dima; J R Banavar; M Cieplak; A Maritan
Journal:  Proc Natl Acad Sci U S A       Date:  1999-04-27       Impact factor: 11.205

2.  Three-helix-bundle protein in a Ramachandran model.

Authors:  A Irbäck; F Sjunnesson; S Wallin
Journal:  Proc Natl Acad Sci U S A       Date:  2000-12-05       Impact factor: 11.205

3.  A minimalist model protein with multiple folding funnels.

Authors:  C R Locker; R Hernandez
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-24       Impact factor: 11.205

4.  Gel catalysts that switch on and off.

Authors:  G Wang; K Kuroda; T Enoki; A Grosberg; S Masamune; T Oya; Y Takeoka; T Tanaka
Journal:  Proc Natl Acad Sci U S A       Date:  2000-08-29       Impact factor: 11.205

5.  Inclusion of persistence length-based secondary structure in replica field theoretic models of heteropolymer freezing.

Authors:  Jeffrey K Weber; Vijay S Pande
Journal:  J Chem Phys       Date:  2013-09-28       Impact factor: 3.488

6.  Unraveling principles of lead discovery: from unfrustrated energy landscapes to novel molecular anchors.

Authors:  P A Rejto; G M Verkhivker
Journal:  Proc Natl Acad Sci U S A       Date:  1996-08-20       Impact factor: 11.205

7.  Evolution of the folding ability of proteins through functional selection.

Authors:  S Saito; M Sasai; T Yomo
Journal:  Proc Natl Acad Sci U S A       Date:  1997-10-14       Impact factor: 11.205

8.  Statistical mechanics of simple models of protein folding and design.

Authors:  V S Pande; A Y Grosberg; T Tanaka
Journal:  Biophys J       Date:  1997-12       Impact factor: 4.033

9.  A mean field model of ligand-protein interactions: implications for the structural assessment of human immunodeficiency virus type 1 protease complexes and receptor-specific binding.

Authors:  G M Verkhivker; P A Rejto
Journal:  Proc Natl Acad Sci U S A       Date:  1996-01-09       Impact factor: 11.205

10.  Stability of dense hydrophobic-polar copolymer globules: regular, random and designed sequences.

Authors:  E N Govorun; A R Khokhlov; A N Semenov
Journal:  Eur Phys J E Soft Matter       Date:  2003-10       Impact factor: 1.890
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.