| Literature DB >> 7803522 |
Y Sasaki1, T Usui, I Tanaka, O Nakagawa, T Sando, T Takahashi, T Namba, S Narumiya, K Nakao.
Abstract
A cDNA clone for rat prostacyclin receptor was isolated. The cDNA encodes a protein of 416 amino acid residues (M(r) 44,662) with putative seven transmembrane domains, and belongs to the G protein-coupled receptor superfamily. Specific binding of [3H]iloprost was found in membrane of COS-7 cells transfected with the cDNA (Kd = 1.3 nM) and was displaced with unlabeled prostaglandins in the order of iloprost = cicaprost > PGE1 > STA2 = PGE2 = PGD2 > PGF2 alpha. Northern blot analysis demonstrated that rat prostacyclin receptor mRNA is expressed in the lung, spleen, heart, pancreas, thymus, stomach and aorta.Entities:
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Year: 1994 PMID： 7803522 DOI： 10.1016/0167-4889(94)90300-x
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002