Literature DB >> 7802859

A new antibiotic, cypemycin. Taxonomy, fermentation, isolation and biological characteristics.

K Komiyama1, K Otoguro, T Segawa, K Shiomi, H Yang, Y Takahashi, M Hayashi, T Otani, S Omura.   

Abstract

A new peptide antibiotic, cypemycin, with a molecular weight of 2,097 (M+H), was isolated from the culture broth of Streptomyces sp. OH-4156. The antibiotic possesses cytocidal activity against P388 leukemia cells in vitro at a concentration of 1.3 microgram/ml (IC50 values), and the antibiotic showed antimicrobial activities against Micrococcus luteus (MIC, 0.2 microgram/ml).

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Year:  1993        PMID： 7802859     DOI： 10.7164/antibiotics.46.1666

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  8 in total

1.  Genome mining and genetic analysis of cypemycin biosynthesis reveal an unusual class of posttranslationally modified peptides.

Authors:  Jan Claesen; Mervyn Bibb
Journal:  Proc Natl Acad Sci U S A       Date:  2010-08-30       Impact factor: 11.205

2.  Catalytic promiscuity of a bacterial α-N-methyltransferase.

Authors:  Qi Zhang; Wilfred A van der Donk
Journal:  FEBS Lett       Date:  2012-07-25       Impact factor: 4.124

Review 3.  Ribosomal peptide natural products: bridging the ribosomal and nonribosomal worlds.

Authors:  John A McIntosh; Mohamed S Donia; Eric W Schmidt
Journal:  Nat Prod Rep       Date:  2009-04       Impact factor: 13.423

4.  Bioinformatic and Reactivity-Based Discovery of Linaridins.

Authors:  Matthew A Georgiou; Shravan R Dommaraju; Xiaorui Guo; David H Mast; Douglas A Mitchell
Journal:  ACS Chem Biol       Date:  2020-11-10       Impact factor: 5.100

5.  Biosynthesis and regulation of grisemycin, a new member of the linaridin family of ribosomally synthesized peptides produced by Streptomyces griseus IFO 13350.

Authors:  Jan Claesen; Mervyn J Bibb
Journal:  J Bacteriol       Date:  2011-03-18       Impact factor: 3.490

Review 6.  New developments in RiPP discovery, enzymology and engineering.

Authors:  Manuel Montalbán-López; Thomas A Scott; Sangeetha Ramesh; Imran R Rahman; Auke J van Heel; Jakob H Viel; Vahe Bandarian; Elke Dittmann; Olga Genilloud; Yuki Goto; María José Grande Burgos; Colin Hill; Seokhee Kim; Jesko Koehnke; John A Latham; A James Link; Beatriz Martínez; Satish K Nair; Yvain Nicolet; Sylvie Rebuffat; Hans-Georg Sahl; Dipti Sareen; Eric W Schmidt; Lutz Schmitt; Konstantin Severinov; Roderich D Süssmuth; Andrew W Truman; Huan Wang; Jing-Ke Weng; Gilles P van Wezel; Qi Zhang; Jin Zhong; Jörn Piel; Douglas A Mitchell; Oscar P Kuipers; Wilfred A van der Donk
Journal:  Nat Prod Rep       Date:  2020-09-16       Impact factor: 15.111

7.  Nucleophilic 1,4-additions for natural product discovery.

Authors:  Courtney L Cox; Jonathan I Tietz; Karol Sokolowski; Joel O Melby; James R Doroghazi; Douglas A Mitchell
Journal:  ACS Chem Biol       Date:  2014-06-17       Impact factor: 5.100

Review 8.  Substrate specificity of the cypemycin decarboxylase CypD.

Authors:  Wei Ding; Tianlu Mo; Dhanaraju Mandalapu; Qi Zhang
Journal:  Synth Syst Biotechnol       Date:  2018-09-15
  8 in total

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