Literature DB >> 7802663

Novel role of vitamin K2: a potent inducer of differentiation of various human myeloid leukemia cell lines.

I Sakai1, S Hashimoto, M Yoda, T Hida, S Ohsawa, S Nakajo, K Nakaya.   

Abstract

When myeloblastic ML1 cells were cultured in the presence of Vitamin K2 (menaquinone, VK2), the population of cells capable of reducing NBT increased to 83.5% at low VK2 concentration of 1 microM, indicating VK2 induces cellular differentiation. VK2 also exerted differentiation-inducing action on histiocytic U937 and promyelocytic HL60 cell lines. None of these effects were observed with Vitamin K1 (phylloquinone, VK1), suggesting the geranylgeranyl group of the side chain of VK2 to be essential to these effects. Combinations of VK2 with other differentiation-inducers such as interferon-gamma, retinoic acid, or camptothecin additively or synergistically induced the differentiation of HL-60 cells. These results suggest that VK2 may safely be used in differentiation therapy in combination with other inducers.

Entities:  

Mesh：

Substances：

Year:  1994        PMID： 7802663     DOI： 10.1006/bbrc.1994.2807

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  8 in total

1.  Cytotoxic effect through fas/APO-1 expression due to vitamin K in human glioma cells.

Authors:  L K Sun; Y Yoshii; K Miyagi
Journal:  J Neurooncol       Date:  2000-03       Impact factor: 4.130

2.  Synergistic growth inhibition in HL-60 cells by the combination of acyclic retinoid and vitamin K2.

Authors:  Junichi Kitagawa; Takeshi Hara; Hisashi Tsurumi; Soranobu Ninomiya; Kengo Ogawa; Seiji Adachi; Nobuhiro Kanemura; Senji Kasahara; Masahito Shimizu; Hisataka Moriwaki
Journal:  J Cancer Res Clin Oncol       Date:  2010-07-31       Impact factor: 4.553

3.  Asian Pacific Association for the Study of the Liver consensus recommendations on hepatocellular carcinoma.

Authors:  Masao Omata; Laurentius A Lesmana; Ryosuke Tateishi; Pei-Jer Chen; Shi-Ming Lin; Haruhiko Yoshida; Masatoshi Kudo; Jeong Min Lee; Byung Ihn Choi; Ronnie T P Poon; Shuichiro Shiina; Ann Lii Cheng; Ji-Dong Jia; Shuntaro Obi; Kwang Hyub Han; Wasim Jafri; Pierce Chow; Seng Gee Lim; Yogesh K Chawla; Unggul Budihusodo; Rino A Gani; C Rinaldi Lesmana; Terawan Agus Putranto; Yun Fan Liaw; Shiv Kumar Sarin
Journal:  Hepatol Int       Date:  2010-03-18       Impact factor: 6.047

Review 4.  Vitamin K and hepatocellular carcinoma: The basic and clinic.

Authors:  Xia Jinghe; Toshihiko Mizuta; Iwata Ozaki
Journal:  World J Clin Cases       Date:  2015-09-16       Impact factor: 1.337

5.  Induction of apoptosis in PA-1 ovarian cancer cells by vitamin K2 is associated with an increase in the level of TR3/Nur77 and its accumulation in mitochondria and nuclei.

Authors:  Toshiko Sibayama-Imazu; Yukari Fujisawa; Yutaka Masuda; Toshihiro Aiuchi; Shigeo Nakajo; Hiroyuki Itabe; Kazuyasu Nakaya
Journal:  J Cancer Res Clin Oncol       Date:  2008-01-17       Impact factor: 4.553

6.  Vitamin K2 and cotylenin A synergistically induce monocytic differentiation and growth arrest along with the suppression of c-MYC expression and induction of cyclin G2 expression in human leukemia HL-60 cells.

Authors:  Yasuhisa Maniwa; Takashi Kasukabe; Shunichi Kumakura
Journal:  Int J Oncol       Date:  2015-06-04       Impact factor: 5.650

Review 7.  The health benefits of vitamin K.

Authors:  James J DiNicolantonio; Jaikrit Bhutani; James H O'Keefe
Journal:  Open Heart       Date:  2015-10-06

8.  Growth Inhibitory Effects of Ester Derivatives of Menahydroquinone-4, the Reduced Form of Vitamin K2(20), on All-Trans Retinoic Acid-Resistant HL60 Cell Line.

Authors:  Hirofumi Yamakawa; Shuichi Setoguchi; Shotaro Goto; Daisuke Watase; Kazuki Terada; Nami Nagata-Akaho; Erina Toki; Mitsuhisa Koga; Kazuhisa Matsunaga; Yoshiharu Karube; Jiro Takata
Journal:  Pharmaceutics       Date:  2021-05-20       Impact factor: 6.321
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.