Literature DB >> 7798145

Two genes encoding uracil phosphoribosyltransferase are present in Bacillus subtilis.

J Martinussen1, P Glaser, P S Andersen, H H Saxild.   

Abstract

Uracil phosphoribosyltransferase (UPRTase) catalyzes the key reaction in the salvage of uracil in many microorganisms. Surprisingly, two genes encoding UPRTase activity were cloned from Bacillus subtilis by complementation of an Escherichia coli mutant. The genes were sequenced, and the putative amino acid sequences were deduced. One gene showed a high level of homology to UPRTases from other organisms, whereas the other gene with a low level of homology to other UPRTases turned out to be the pyrR gene--the repressor of the pyr operon. The role of these genes in uracil metabolism was established by an analysis of the phenotypes of upp and pyrR mutants.

Entities:  

Mesh：

Substances：

Year:  1995        PMID： 7798145      PMCID： PMC176586          DOI： 10.1128/jb.177.1.271-274.1995

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  10 in total

1.  TRANSFORMATION OF BIOCHEMICALLY DEFICIENT STRAINS OF BACILLUS SUBTILIS BY DEOXYRIBONUCLEATE.

Authors:  J Spizizen
Journal:  Proc Natl Acad Sci U S A       Date:  1958-10-15       Impact factor: 11.205

2.  Mutations affecting uridine monophosphate pyrophosphorylase or the argR gene in Escherichia coli. Effects on carbamoyl phosphate and pyrimidine biosynthesis and on uracil uptake.

Authors:  A Piérard; N Glansdorff; J Yashphe
Journal:  Mol Gen Genet       Date:  1972

3.  Purification and some properties of uracil phosphoribosyltransferase from Escherichia coli K12.

Authors:  U B Rasmussen; B Mygind; P Nygaard
Journal:  Biochim Biophys Acta       Date:  1986-04-11

4.  Regulation of the Bacillus subtilis pyrimidine biosynthetic (pyr) gene cluster by an autogenous transcriptional attenuation mechanism.

Authors:  R J Turner; Y Lu; R L Switzer
Journal:  J Bacteriol       Date:  1994-06       Impact factor: 3.490

5.  An improved positive selection plasmid vector constructed by oligonucleotide mediated mutagenesis.

Authors:  B Nilsson; M Uhlén; S Josephson; S Gatenbeck; L Philipson
Journal:  Nucleic Acids Res       Date:  1983-11-25       Impact factor: 16.971

6.  Genetic and physiological characterization of Bacillus subtilis mutants resistant to purine analogs.

Authors:  H H Saxild; P Nygaard
Journal:  J Bacteriol       Date:  1987-07       Impact factor: 3.490

7.  Functional organization and nucleotide sequence of the Bacillus subtilis pyrimidine biosynthetic operon.

Authors:  C L Quinn; B T Stephenson; R L Switzer
Journal:  J Biol Chem       Date:  1991-05-15       Impact factor: 5.157

8.  The ftf gene encoding the cell-bound fructosyltransferase of Streptococcus salivarius ATCC 25975 is preceded by an insertion sequence and followed by FUR1 and clpP homologues.

Authors:  P M Giffard; C Rathsam; E Kwan; D W Kwan; K L Bunny; S P Koo; N A Jacques
Journal:  J Gen Microbiol       Date:  1993-05

9.  Characterization of the upp gene encoding uracil phosphoribosyltransferase of Escherichia coli K12.

Authors:  P S Andersen; J M Smith; B Mygind
Journal:  Eur J Biochem       Date:  1992-02-15

10.  DNA sequencing with chain-terminating inhibitors.

Authors:  F Sanger; S Nicklen; A R Coulson
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205
  10 in total
  14 in total

1.  The pyrimidine operon pyrRPB-carA from Lactococcus lactis.

Authors:  J Martinussen; J Schallert; B Andersen; K Hammer
Journal:  J Bacteriol       Date:  2001-05       Impact factor: 3.490

2.  Structure of the nucleotide complex of PyrR, the pyr attenuation protein from Bacillus caldolyticus, suggests dual regulation by pyrimidine and purine nucleotides.

Authors:  Preethi Chander; Kari M Halbig; Jamie K Miller; Christopher J Fields; Heather K S Bonner; Gail K Grabner; Robert L Switzer; Janet L Smith
Journal:  J Bacteriol       Date:  2005-03       Impact factor: 3.490

Review 3.  Regulation of Bacterial Gene Expression by Transcription Attenuation.

Authors:  Charles L Turnbough
Journal:  Microbiol Mol Biol Rev       Date:  2019-07-03       Impact factor: 11.056

4.  Structure and expression of a pyrimidine gene cluster from the extreme thermophile Thermus strain ZO5.

Authors:  M Van de Casteele; P Chen; M Roovers; C Legrain; N Glansdorff
Journal:  J Bacteriol       Date:  1997-06       Impact factor: 3.490

5.  Dra-nupC-pdp operon of Bacillus subtilis: nucleotide sequence, induction by deoxyribonucleosides, and transcriptional regulation by the deoR-encoded DeoR repressor protein.

Authors:  H H Saxild; L N Andersen; K Hammer
Journal:  J Bacteriol       Date:  1996-01       Impact factor: 3.490

6.  Uracil salvage pathway in Lactobacillus plantarum: Transcription and genetic studies.

Authors:  Florence Arsène-Ploetze; Hervé Nicoloff; Benoît Kammerer; Jan Martinussen; Françoise Bringel
Journal:  J Bacteriol       Date:  2006-07       Impact factor: 3.490

7.  Repression of the pyr operon in Lactobacillus plantarum prevents its ability to grow at low carbon dioxide levels.

Authors:  Hervé Nicoloff; Aram Elagöz; Florence Arsène-Ploetze; Benoît Kammerer; Jan Martinussen; Françoise Bringel
Journal:  J Bacteriol       Date:  2005-03       Impact factor: 3.490

Review 8.  Regulation of pyrimidine biosynthetic gene expression in bacteria: repression without repressors.

Authors:  Charles L Turnbough; Robert L Switzer
Journal:  Microbiol Mol Biol Rev       Date:  2008-06       Impact factor: 11.056

9.  Duplicate isochorismate synthase genes of Bacillus subtilis: regulation and involvement in the biosyntheses of menaquinone and 2,3-dihydroxybenzoate.

Authors:  B M Rowland; H W Taber
Journal:  J Bacteriol       Date:  1996-02       Impact factor: 3.490

10.  Role of adenine deaminase in purine salvage and nitrogen metabolism and characterization of the ade gene in Bacillus subtilis.

Authors:  P Nygaard; P Duckert; H H Saxild
Journal:  J Bacteriol       Date:  1996-02       Impact factor: 3.490
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.