Literature DB >> 7797535

Identification and functional expression of a receptor selectively recognizing parathyroid hormone, the PTH2 receptor.

T B Usdin1, C Gruber, T I Bonner.   

Abstract

We have identified a G-protein-coupled receptor specifically activated by parathyroid hormone, which we refer to as the PTH2 receptor. Parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP, hypercalcemia of malignancy factor) activate a previously identified PTH/PTHrP receptor, which has a widespread tissue distribution. The PTH2 receptor is much more selective in ligand recognition and appears to have a more specific tissue distribution. It is activated by PTH and not by PTHrP and is particularly abundant in the brain and pancreas.

Entities:  

Mesh：

Substances：

Year:  1995        PMID： 7797535     DOI： 10.1074/jbc.270.26.15455

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  70 in total

Review 1.  Interaction of PTH and PTHrP with their receptors.

Authors:  T J Gardella; H Jüppner
Journal:  Rev Endocr Metab Disord       Date:  2000-11       Impact factor: 6.514

Review 2.  PTH and PTHrP effects on the skeleton.

Authors:  A C Karaplis; D Goltzman
Journal:  Rev Endocr Metab Disord       Date:  2000-11       Impact factor: 6.514

Review 3.  Clinical spectrum and pathogenesis of pseudohypoparathyroidism.

Authors:  M A Levine
Journal:  Rev Endocr Metab Disord       Date:  2000-11       Impact factor: 6.514

4.  Anatomical and physiological evidence for involvement of tuberoinfundibular peptide of 39 residues in nociception.

Authors:  Arpad Dobolyi; Hiroshi Ueda; Hitoshi Uchida; Miklós Palkovits; Ted B Usdin
Journal:  Proc Natl Acad Sci U S A       Date:  2002-01-29       Impact factor: 11.205

Review 5.  The PTH/PTHrP receptor in Jansen's metaphyseal chondrodysplasia.

Authors:  L M Calvi; E Schipani
Journal:  J Endocrinol Invest       Date:  2000-09       Impact factor: 4.256

Review 6.  Hormonal regulation and implication of cell signaling in calcium transfer by placenta.

Authors:  J Lafond; I Goyer-O'Reilly; M Laramée; L Simoneau
Journal:  Endocrine       Date:  2001-04       Impact factor: 3.633

7.  Bone-targeting parathyroid hormone conjugates outperform unmodified PTH in the anabolic treatment of osteoporosis in rats.

Authors:  Yang Yang; Ali Aghazadeh-Habashi; Arash Panahifar; Yuchin Wu; Krishna H Bhandari; Michael R Doschak
Journal:  Drug Deliv Transl Res       Date:  2017-08       Impact factor: 4.617

8.  Osteoarthritis susceptibility loci defined by genome scan meta-analysis.

Authors:  Young Ho Lee; Young Hee Rho; Seong Jae Choi; Jong Dae Ji; Gwan Gyu Song
Journal:  Rheumatol Int       Date:  2006-04-01       Impact factor: 2.631

9.  Signaling by N- and C-terminal sequences of parathyroid hormone-related protein in hippocampal neurons.

Authors:  S Fukayama; A H Tashjian; J N Davis; J C Chisholm
Journal:  Proc Natl Acad Sci U S A       Date:  1995-10-24       Impact factor: 11.205

10.  Expression of osteogenic molecules in the caudate nucleus and gray matter and their potential relevance for Basal Ganglia calcification in hypoparathyroidism.

Authors:  Ravinder Goswami; Tabin Millo; Shruti Mishra; Madhuchhanda Das; Mansi Kapoor; Neeraj Tomar; Soma Saha; Tara Shankar Roy; Vishnubhatla Sreenivas
Journal:  J Clin Endocrinol Metab       Date:  2014-02-19       Impact factor: 5.958
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.