Literature DB >> 779562

Inhibition of stimulated gastric secretion by an orally administered prostaglandin capsule. A study in normal men.

D E Wilson, J Quertermus, M Raiser, J Curran, A Robért.   

Abstract

The effect of ingestion of a gelatin capsule containing 127 mug of 16,16-dimethyl prostaglandin E2 (DM-prostaglandin E2) or a liquid containing 127 mug of DM-prostaglandin E2 on stimulated gastric secretion in man was studied. DM-prostaglandin E2 significantly reduced the volume, acid concentration, and total acid output of gastric secretion. Secretory inhibition during the 3 h after treatment with the capsule was 37% (volume), 39% (acid concentration), and 60% (acid output). The DM-prostaglandin E2 capsule was nearly as effective as equivalent amount of DM-prostaglandin E2 in solution. Prostaglandin analogues, because of their oral effectiveness and duration of action, may have therapeutic value in peptic ulcer disease.

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Year:  1976        PMID： 779562     DOI： 10.7326/0003-4819-84-6-688

Source DB:  PubMed          Journal:  Ann Intern Med        ISSN： 0003-4819            Impact factor:   25.391


  10 in total

1.  Effect of synthetic prostaglandin E1 analog on gastric emptying of meals in man.

Authors:  J G Moore; N Alazraki; G D Clay
Journal:  Dig Dis Sci       Date:  1986-01       Impact factor: 3.199

2.  The effect of 15(R)-15-methyl prostaglandin E2 on meal-stimulated gastric acid secretion, serum gastrin, and pancreatic polypeptide in duodenal ulcer patients.

Authors:  W Peterson; M Feldman; I Taylor; M Bremer
Journal:  Dig Dis Sci       Date:  1979-05       Impact factor: 3.199

3.  Inhibition of canine gastric secretion by the prostanoid Ro 22-6923.

Authors:  T S Gaginella; R J Bertko; R K Müller; H Gallo-Torres; A C Sullivan
Journal:  Dig Dis Sci       Date:  1985-04       Impact factor: 3.199

4.  Papaverine stimulation of prostaglandin E2 production by cultured rabbit gastric mucosa.

Authors:  M Ligumsky; D Rachmilewitz; U Zor
Journal:  Gut       Date:  1979-10       Impact factor: 23.059

5.  The effects of a prostaglandin endoperoxide analogue on canine gastric acid and mucus secretion.

Authors:  P Tao; W Scruggs; D E Wilson
Journal:  Dig Dis Sci       Date:  1979-06       Impact factor: 3.199

6.  Effects of aspirin and prostaglandin E2 on interdigestive motility complex and duodenogastric reflux in man.

Authors:  C P Dooley; W D Mello; J E Valenzuela
Journal:  Dig Dis Sci       Date:  1985-06       Impact factor: 3.199

7.  Effect of 16, 16-dimethyl PGE2 on resting and histamine-stimulated gastric mucosal blood flow.

Authors:  T A Miller; J M Henagan; A Robert
Journal:  Dig Dis Sci       Date:  1980-08       Impact factor: 3.199

8.  Misoprostol, a synthetic PGE1 analog, in the treatment of duodenal ulcers. A multicenter double-blind study.

Authors:  D L Brand; W M Roufail; A B Thomson; E J Tapper
Journal:  Dig Dis Sci       Date:  1985-11       Impact factor: 3.199

9.  Effect of 15(R),15-methyl prostaglandin E2 and indomethacin on pancreatic secretion in man.

Authors:  C Saad; C P Dooley; J E Valenzuela
Journal:  Dig Dis Sci       Date:  1987-05       Impact factor: 3.199

10.  Prostaglandin-modulated umbilical cord blood hematopoietic stem cell transplantation.

Authors:  Corey Cutler; Pratik Multani; David Robbins; Haesook T Kim; Thuy Le; Jonathan Hoggatt; Louis M Pelus; Caroline Desponts; Yi-Bin Chen; Betsy Rezner; Philippe Armand; John Koreth; Brett Glotzbecker; Vincent T Ho; Edwin Alyea; Marlisa Isom; Grace Kao; Myriam Armant; Leslie Silberstein; Peirong Hu; Robert J Soiffer; David T Scadden; Jerome Ritz; Wolfram Goessling; Trista E North; John Mendlein; Karen Ballen; Leonard I Zon; Joseph H Antin; Daniel D Shoemaker
Journal:  Blood       Date:  2013-08-30       Impact factor: 22.113
  10 in total

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