Literature DB >> 456224

The effect of 15(R)-15-methyl prostaglandin E2 on meal-stimulated gastric acid secretion, serum gastrin, and pancreatic polypeptide in duodenal ulcer patients.

W Peterson, M Feldman, I Taylor, M Bremer.   

Abstract

The effects of 100-microgram of 15(R)-15-methyl prostaglandin E2 on meal-stimulated acid secretion, serum gastrin, and pancreatic polypeptide concentrations were measured in patients with duodenal ulcer. The drug given in encapsulated or unencapsulated form significantly reduced gastric acid secretion by 59% or 70%, respectively. Rises in serum gastrin and pancreatic polypeptide concentrations after the meal were significantly blunted by 15(R)-15-methyl prostaglandin E2. This dose of prostaglandin led to no side effects and merits clinical evaluation in the treatment of peptic ulcer disease.

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Year:  1979        PMID： 456224     DOI： 10.1007/bf01297125

Source DB:  PubMed          Journal:  Dig Dis Sci        ISSN： 0163-2116            Impact factor:   3.199


  16 in total

1.  Effect of methylated PGE2 analogs given orally on pancreatic response to secretin in man.

Authors:  S J Konturek; N Kwiecień; J Swierczek; J Oleksy
Journal:  Am J Dig Dis       Date:  1977-01

2.  Effect of selective proximal vagotomy on food-stimulated gastric acid secretion and gastrin release in patients with duodenal ulcer.

Authors:  M Feldman; R M Dickerman; R N McClelland; K A Cooper; J H Walsh; C T Richardson
Journal:  Gastroenterology       Date:  1979-05       Impact factor: 22.682

3.  Effect of low-dose propantheline on food-stimulated gastric acid secretion: comparison with an "optimal effective dose" and interaction with cimetidine.

Authors:  M Feldman; C T Richardson; W L Peterson; J H Walsh; J S Fordtran
Journal:  N Engl J Med       Date:  1977-12-29       Impact factor: 91.245

4.  The effect of cimetidine, a new histamine H2-receptor antagonist, on meal-stimulated acid secretion, serum gastrin, and gastric emptying in patients with duodenal ulcer.

Authors:  C T Richardson; J H Walsh; M I Hicks
Journal:  Gastroenterology       Date:  1976-07       Impact factor: 22.682

5.  Inhibition of gastric secretion in man by prostaglandin A.

Authors:  D E Wilson; C Phillips; R A Levine
Journal:  Gastroenterology       Date:  1971-08       Impact factor: 22.682

6.  The effect of 15 (R) 15 methyl prostaglandin E2 on gastric acid secretion in duodenal ulcer patients.

Authors:  F W Chen; H S Teck; S M Karim
Journal:  Prostaglandins       Date:  1977-01

7.  Gastric antisecretory effect of 15(R)-15-menthyl PGE2, methyl ester and of 15(S)-15-methyl ester.

Authors:  A Robert; E W Yankee
Journal:  Proc Soc Exp Biol Med       Date:  1975-04

8.  Inhibition of stimulated gastric secretion by an orally administered prostaglandin capsule. A study in normal men.

Authors:  D E Wilson; J Quertermus; M Raiser; J Curran; A Robért
Journal:  Ann Intern Med       Date:  1976-06       Impact factor: 25.391

9.  Gastric acid secretion rate and buffer content of the stomach after eating. Results in normal subjects and in patients with duodenal ulcer.

Authors:  J S Fordtran; J H Walsh
Journal:  J Clin Invest       Date:  1973-03       Impact factor: 14.808

10.  Pancreatic polypeptide. Metabolism and effect on pancreatic secretion in dogs.

Authors:  I L Taylor; T E Solomon; J H Walsh; M I Grossman
Journal:  Gastroenterology       Date:  1979-03       Impact factor: 22.682
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  14 in total

1.  Effect of rioprostil, a methylprostaglandin E1 analog, on basal and stimulated plasma pancreatic hormone levels in man.

Authors:  O Segers; G Somers
Journal:  Dig Dis Sci       Date:  1990-01       Impact factor: 3.199

2.  Effect of misoprostol, an antiulcer prostaglandin, on serum gastrin in patients with duodenal ulcer.

Authors:  J E McGuigan; Y Chang; E Z Dajani
Journal:  Dig Dis Sci       Date:  1986-02       Impact factor: 3.199

3.  Arbaprostil (15(R)-15-methyl PGE2): lack of effect on theophylline metabolism.

Authors:  S B Reele; A Euler; J McEvers; C Metzler
Journal:  Br J Clin Pharmacol       Date:  1986-02       Impact factor: 4.335

Review 4.  The significance of gastrin in the pathogenesis and therapy of peptic ulcer disease.

Authors:  C B Lamers
Journal:  Drugs       Date:  1988       Impact factor: 9.546

5.  Absorption, tissue distribution, and excretion of 3H-labeled arbaprostil in the male rat.

Authors:  A J Sinha; S R Shaw; B A Thornburgh
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1985 Apr-Jun       Impact factor: 2.441

6.  Diflunisal protects human gastric mucosa against damage by indomethacin.

Authors:  M M Cohen
Journal:  Dig Dis Sci       Date:  1983-12       Impact factor: 3.199

7.  Dose response inhibition in man of meal-stimulated gastric acid secretion by 15(R)-15-methyl prostaglandin E2, given orally.

Authors:  A Robert; G Kane; S B Reele
Journal:  Gut       Date:  1981-09       Impact factor: 23.059

8.  Effect of synthetic prostaglandin E1 analog (ornoprostil) on gastric emptying and pancreatic polypeptide release after solid-meal ingestion in man.

Authors:  H Okano; S Saeki; A Inui; Y Kawai; S Morimoto; A Ohmoto; T Nakashima; M Miyamoto; T Oh; A Takata
Journal:  Dig Dis Sci       Date:  1991-01       Impact factor: 3.199

9.  Reduction of aspirin-induced fecal blood loss with low-dose misoprostol tablets in man.

Authors:  M M Cohen; L Clark; L Armstrong; J D'Souza
Journal:  Dig Dis Sci       Date:  1985-07       Impact factor: 3.199

10.  Isolation and characterization of the urinary metabolites of arbaprostil in the male dog after intravenous administration.

Authors:  B A Thornburgh; S R Shaw; G E Bronson; A J Sinha
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1988 Apr-Jun       Impact factor: 2.441
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