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Literature DB >> 7777524

Library of libraries: approach to synthetic combinatorial library design and screening of "pharmacophore" motifs.

N F Sepetov¹, V Krchnák, M Stanková, S Wade, K S Lam, M Lebl.

Abstract

Construction of synthetic combinatorial libraries is described that allows for the generation of a library of motifs rather than a library of compounds. Peptide libraries based on this strategy were synthesized and screened with model targets streptavidin and anti-beta-endorphin antibody. The screens resulted in observation of expected motifs providing evidence of the effectiveness of the suggested approach.

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Year: 1995 PMID： 7777524 PMCID： PMC41707 DOI： 10.1073/pnas.92.12.5426

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

14 in total

1. Rapid identification of high affinity peptide ligands using positional scanning synthetic peptide combinatorial libraries.

Authors: C Pinilla; J R Appel; P Blanc; R A Houghten
Journal: Biotechniques Date: 1992-12 Impact factor: 1.993

9. The use of positional scanning synthetic peptide combinatorial libraries for the rapid determination of opioid receptor ligands.

Authors: C T Dooley; R A Houghten
Journal: Life Sci Date: 1993 Impact factor: 5.037

Library of libraries: approach to synthetic combinatorial library design and screening of "pharmacophore" motifs.

1. Rapid identification of high affinity peptide ligands using positional scanning synthetic peptide combinatorial libraries.

2. A new type of synthetic peptide library for identifying ligand-binding activity.

3. General method for rapid synthesis of multicomponent peptide mixtures.

4. A priori delineation of a peptide which mimics a discontinuous antigenic determinant.

5. Light-directed, spatially addressable parallel chemical synthesis.

6. The rapid identification of HIV protease inhibitors through the synthesis and screening of defined peptide mixtures.

7. Random peptide libraries: a source of specific protein binding molecules.

Review 8. One-bead-one-structure combinatorial libraries.

9. The use of positional scanning synthetic peptide combinatorial libraries for the rapid determination of opioid receptor ligands.

10. A cleavage method which minimizes side reactions following Fmoc solid phase peptide synthesis.

1. Peptomers: a versatile approach for the preparation of diverse combinatorial peptidomimetic bead libraries.

Review 2. Synthetic library techniques: subjective (biased and generic) thoughts and views.