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Literature DB >> 7775257

Frequent genetic instability in small intestinal carcinomas.

K Hibi¹, K Kondo, S Akiyama, K Ito, H Takagi.

Abstract

To determine whether genetic instability plays a part in the development of digestive tract carcinomas, we analyzed 3 microsatellite loci isolated from tumors and surrounding normal tissue samples obtained during surgery. The polymerase chain reaction (PCR) technique was used to assess differences between tumor and matched normal DNAs. Replication errors (RERs) were observed in 3 of the 29 cases (10%) of gastric carcinoma and in 11 of the 72 cases (15%) of colorectal carcinoma. None of the 13 (0%) esophageal carcinoma cases showed any RER, but 5 of the 11 cases of small intestinal carcinoma (45%) had RERs, a significantly frequent finding. These results suggest that genetic instability plays an important role in the pathogenesis of small intestinal carcinomas.

Entities: CellLine Chemical Disease Gene Species

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Year: 1995 PMID： 7775257 PMCID： PMC5920835 DOI： 10.1111/j.1349-7006.1995.tb03064.x

Source DB: PubMed Journal: Jpn J Cancer Res ISSN： 0910-5050

20 in total

Frequent genetic instability in small intestinal carcinomas.

1. Dinucleotide repeat polymorphism at the D18S34 locus.

2. Purification of DNA from formaldehyde fixed and paraffin embedded human tissue.

3. Prevalence of ras gene mutations in human colorectal cancers.

4. Mutations in the p53 gene occur in diverse human tumour types.

5. Microsatellite instability in cancer of the proximal colon.

6. Clues to the pathogenesis of familial colorectal cancer.

7. Frequent microsatellite instability in primary small cell lung cancer.

8. Genetic instability in pancreatic cancer and poorly differentiated type of gastric cancer.

9. Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer.

10. Replication errors in benign and malignant tumors from hereditary nonpolyposis colorectal cancer patients.

1. Combination analysis of genetic alterations and cell proliferation in small intestinal carcinomas.

2. An insight into the genetic pathway of adenocarcinoma of the small intestine.

3. Loss of heterozygosity of microsatellite loci on chromosome 9p in astrocytic tumors and its prognostic implications.

4. Midgut Carcinoids and Solid Carcinomas of the Intestine: Differences in Endocrine Markers and p53 Mutations.

5. Immunohistochemical analysis of adenocarcinoma of the small intestine: a tissue microarray study.

6. Alternative splicing of the FHIT gene in colorectal cancers.

7. Immunophenotype and molecular characterisation of adenocarcinoma of the small intestine.