| Literature DB >> 3587348 |
J L Bos, E R Fearon, S R Hamilton, M Verlaan-de Vries, J H van Boom, A J van der Eb, B Vogelstein.
Abstract
A combination of DNA hybridization analyses and tissue sectioning techniques demonstrate that ras gene mutations occur in over a third of human colorectal cancers, that most of the mutations are at codon 12 of the c-Ki-ras gene and that the mutations usually precede the development of malignancy.Entities:
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Year: 1987 PMID： 3587348 DOI： 10.1038/327293a0
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962