Literature DB >> 7775255

Frequent loss of the cyclin-dependent kinase-4 inhibitor gene in human gliomas.

A Gomi1, R Sakai, S Ogawa, S Shinoda, H Hirai, T Masuzawa.   

Abstract

Studies have shown that homozygous deletion of the cyclin-dependent kinase-4 inhibitor (CDK4I) gene, which is mapped to chromosome 9p21, is frequently observed in various types of human cancers. Here we report that the CDK4I gene was deleted in gliomas. Eight cell lines derived from glioblastomas and samples from 14 patients with various grades of gliomas were examined by Southern blot analysis. We found that the CDK4I gene was deleted in 7 of 8 (87.5%) cell lines and 7 of 9 (78%) samples from high-grade glioma patients, whereas it was deleted in 1 of 5 (20%) low-grade glioma samples. These results suggested that inactivation of the CDK4I gene may play an important role in the progression of human glioma.

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Year:  1995        PMID： 7775255      PMCID： PMC5920832          DOI： 10.1111/j.1349-7006.1995.tb03062.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


  26 in total

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Journal:  Curr Opin Oncol       Date:  1990-08       Impact factor: 3.645

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Journal:  Cancer Res       Date:  1992-05-01       Impact factor: 12.701

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Journal:  Cancer Res       Date:  1994-01-15       Impact factor: 12.701

4.  Homozygous deletion on chromosome 9p and loss of heterozygosity on 9q, 6p, and 6q in primary human small cell lung cancer.

Authors:  A Merlo; E Gabrielson; M Mabry; R Vollmer; S B Baylin; D Sidransky
Journal:  Cancer Res       Date:  1994-05-01       Impact factor: 12.701

5.  Localization of chromosome 9p homozygous deletions in glioma cell lines with markers constituting a continuous linkage group.

Authors:  C D James; J He; V P Collins; M J Allalunis-Turner; R S Day
Journal:  Cancer Res       Date:  1993-08-15       Impact factor: 12.701

6.  Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers.

Authors:  T Nobori; K Miura; D J Wu; A Lois; K Takabayashi; D A Carson
Journal:  Nature       Date:  1994-04-21       Impact factor: 49.962

7.  Rates of p16 (MTS1) mutations in primary tumors with 9p loss.

Authors:  P Cairns; L Mao; A Merlo; D J Lee; D Schwab; Y Eby; K Tokino; P van der Riet; J E Blaugrund; D Sidransky
Journal:  Science       Date:  1994-07-15       Impact factor: 47.728

8.  Frequent somatic mutation of the MTS1/CDK4I (multiple tumor suppressor/cyclin-dependent kinase 4 inhibitor) gene in esophageal squamous cell carcinoma.

Authors:  T Mori; K Miura; T Aoki; T Nishihira; S Mori; Y Nakamura
Journal:  Cancer Res       Date:  1994-07-01       Impact factor: 12.701

9.  p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest.

Authors:  G J Hannon; D Beach
Journal:  Nature       Date:  1994-09-15       Impact factor: 49.962

10.  Chromosome 9 deletion mapping reveals interferon alpha and interferon beta-1 gene deletions in human glial tumors.

Authors:  C D James; J He; E Carlbom; M Nordenskjold; W K Cavenee; V P Collins
Journal:  Cancer Res       Date:  1991-03-15       Impact factor: 12.701
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  5 in total

1.  Sense p16 and antisense uPAR bicistronic construct inhibits angiogenesis and induces glioma cell death.

Authors:  Narasimharao Nalabothula; Sajani S Lakka; Dzung H Dinh; Meena Gujrati; William C Olivero; Jasti S Rao
Journal:  Int J Oncol       Date:  2007-03       Impact factor: 5.650

2.  Loss of heterozygosity of microsatellite loci on chromosome 9p in astrocytic tumors and its prognostic implications.

Authors:  M Maruno; T Yoshimine; A K Muhammad; K Tokiyoshi; T Hayakawa
Journal:  J Neurooncol       Date:  1996-10       Impact factor: 4.130

3.  The CDKN2A G500 allele is more frequent in GBM patients with no defined telomere maintenance mechanism tumors and is associated with poorer survival.

Authors:  Janice A Royds; Shafagh Al Nadaf; Anna K Wiles; Yu-Jen Chen; Antonio Ahn; Alisha Shaw; Sara Bowie; Frederic Lam; Bruce C Baguley; Antony W Braithwaite; Martin R MacFarlane; Noelyn A Hung; Tania L Slatter
Journal:  PLoS One       Date:  2011-10-26       Impact factor: 3.240

4.  Primary malignant lymphoma of the brain: demonstration of frequent p16 and p15 gene deletions.

Authors:  T Kumanishi; S Zhang; T Ichikawa; S Endo; K Washiyama
Journal:  Jpn J Cancer Res       Date:  1996-07

5.  A comparative study of glioma cell lines for p16, p15, p53 and p21 gene alterations.

Authors:  S Zhang; S Endo; H Koga; T Ichikawa; X Feng; K Onda; K Washiyama; T Kumanishi
Journal:  Jpn J Cancer Res       Date:  1996-09
  5 in total

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