| Literature DB >> 7769308 |
P M Jansen1, J van Damme, W Put, I W de Jong, F B Taylor, C E Hack.
Abstract
The chemokine monocyte chemotactic protein 1 (MCP-1) is a cytokine with chemotactic activity specific for mononuclear phagocytes. To investigate the possible involvement of MCP-1 in the pathogenesis of sepsis, its course was studied in baboons challenged intravenously with a sublethal or lethal dose of Escherichia coli. Levels of MCP-1 started to increase in both groups of animals 2 h after injection of E. coli, reaching peak levels 4 and 6 h after a sublethal (186 +/- 21 ng/mL) or a lethal (213 +/- 24 ng/mL) dose, respectively. Levels of MCP-1 correlated significantly with plasma levels of another chemokine, interleukin-8 (IL-8; r = .826. P < .001), suggesting that common stimuli mediate the release of both cytokines in this model.Entities:
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Year: 1995 PMID： 7769308 DOI： 10.1093/infdis/171.6.1640
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226