Literature DB >> 16982835

Monocyte chemoattractant protein 1 does not contribute to protective immunity against pneumococcal pneumonia.

Mark C Dessing1, Alex F de Vos, Sandrine Florquin, Tom van der Poll.   

Abstract

To determine the role of monocyte chemoattractant protein 1 (MCP-1) during pneumococcal pneumonia, MCP-1 knockout and wild-type mice were infected with Streptococcus pneumoniae. Pulmonary MCP-1 levels were strongly correlated to bacterial loads in wild-type mice. However, MCP-1 knockout and wild-type mice were indistinguishable with respect to bacterial growth, inflammatory responses, and lethality.

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Year:  2006        PMID： 16982835      PMCID： PMC1698042          DOI： 10.1128/IAI.00977-06

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


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