Literature DB >> 7764394

Chaetomella acutiseta produces chaetomellic acids A and B which are reversible inhibitors of farnesyl-protein transferase.

R B Lingham1, K C Silverman, G F Bills, C Cascales, M Sanchez, R G Jenkins, S E Gartner, I Martin, M T Diez, F Peláez.   

Abstract

Chaetomellic acids A and B, isolated from Chaetomella acutiseta, are specific inhibitors of farnesyl-protein transferase that do not inhibit geranylgeranyl transferase type 1 or squalene synthase. Chaetomellic acids A and B are reversible inhibitors, resemble farnesyl diphosphate and probably inhibit FPTase by substituting for farnesyl diphosphate. Chaetomellic acid production appears to be widespread within the genus Chaetomella.

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Year:  1993        PMID： 7764394     DOI： 10.1007/BF00170395

Source DB:  PubMed          Journal:  Appl Microbiol Biotechnol        ISSN： 0175-7598            Impact factor:   4.813


  23 in total

1.  Inhibition of farnesyl-protein transferase by gliotoxin and acetylgliotoxin.

Authors:  D Van der Pyl; J Inokoshi; K Shiomi; H Yang; H Takeshima; S Omura
Journal:  J Antibiot (Tokyo)       Date:  1992-11       Impact factor: 2.649

Review 2.  Protein isoprenylation and methylation at carboxyl-terminal cysteine residues.

Authors:  S Clarke
Journal:  Annu Rev Biochem       Date:  1992       Impact factor: 23.643

Review 3.  Regulation of the mevalonate pathway.

Authors:  J L Goldstein; M S Brown
Journal:  Nature       Date:  1990-02-01       Impact factor: 49.962

Review 4.  Hep G2 cells as a resource for metabolic studies: lipoprotein, cholesterol, and bile acids.

Authors:  N B Javitt
Journal:  FASEB J       Date:  1990-02-01       Impact factor: 5.191

5.  Polyisoprenylation of Ras in vitro by a farnesyl-protein transferase.

Authors:  M D Schaber; M B O'Hara; V M Garsky; S C Mosser; J D Bergstrom; S L Moores; M S Marshall; P A Friedman; R A Dixon; J B Gibbs
Journal:  J Biol Chem       Date:  1990-09-05       Impact factor: 5.157

6.  Characterization of recombinant human farnesyl-protein transferase: cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases.

Authors:  C A Omer; A M Kral; R E Diehl; G C Prendergast; S Powers; C M Allen; J B Gibbs; N E Kohl
Journal:  Biochemistry       Date:  1993-05-18       Impact factor: 3.162

7.  Selective inhibition of farnesyl-protein transferase blocks ras processing in vivo.

Authors:  J B Gibbs; D L Pompliano; S D Mosser; E Rands; R B Lingham; S B Singh; E M Scolnick; N E Kohl; A Oliff
Journal:  J Biol Chem       Date:  1993-04-15       Impact factor: 5.157

8.  Identification of Ras farnesyltransferase inhibitors by microbial screening.

Authors:  M Hara; K Akasaka; S Akinaga; M Okabe; H Nakano; R Gomez; D Wood; M Uh; F Tamanoi
Journal:  Proc Natl Acad Sci U S A       Date:  1993-03-15       Impact factor: 11.205

9.  Selective inhibition of isoprenylation of 21-26-kDa proteins by the anticarcinogen d-limonene and its metabolites.

Authors:  P L Crowell; R R Chang; Z B Ren; C E Elson; M N Gould
Journal:  J Biol Chem       Date:  1991-09-15       Impact factor: 5.157

10.  Sequence dependence of protein isoprenylation.

Authors:  S L Moores; M D Schaber; S D Mosser; E Rands; M B O'Hara; V M Garsky; M S Marshall; D L Pompliano; J B Gibbs
Journal:  J Biol Chem       Date:  1991-08-05       Impact factor: 5.157
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  3 in total

1.  Actinoplanic acids A and B as novel inhibitors of farnesyl-protein transferase.

Authors:  K C Silverman; C Cascales; O Genilloud; J M Sigmund; S E Gartner; G E Koch; M M Gagliardi; B K Heimbuch; M Nallin-Omstead; M Sanchez
Journal:  Appl Microbiol Biotechnol       Date:  1995 Aug-Sep       Impact factor: 4.813

2.  Novel route to chaetomellic acid A and analogues: serendipitous discovery of a more competent FTase inhibitor.

Authors:  Franco Bellesia; Seoung-ryoung Choi; Fulvia Felluga; Giuliano Fiscaletti; Franco Ghelfi; Maria Cristina Menziani; Andrew F Parsons; C Dale Poulter; Fabrizio Roncaglia; Massimo Sabbatini; Domenico Spinelli
Journal:  Bioorg Med Chem       Date:  2012-10-29       Impact factor: 3.641

Review 3.  An overview on natural farnesyltransferase inhibitors for efficient cancer therapy.

Authors:  Xiaohan Dai; Yingni Sun; Ting Zhang; Yongfei Ming; Gao Hongwei
Journal:  J Enzyme Inhib Med Chem       Date:  2020-12       Impact factor: 5.051
  3 in total

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