Literature DB >> 7764209

Gene targeting in mammalian cells by homologous recombination.

B Morrow1, R Kucherlapati.   

Abstract

Gene targeting by homologous recombination is a genetic tool that permits modification of cellular genes in a precise and predetermined fashion. The methodologies that are currently available permit gene targeting at high efficiency and fidelity. New developments promise large-scale modification of the mammalian genome using these techniques.

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Year:  1993        PMID： 7764209     DOI： 10.1016/0958-1669(93)90080-g

Source DB:  PubMed          Journal:  Curr Opin Biotechnol        ISSN： 0958-1669            Impact factor:   9.740


  3 in total

1.  Improved methodology for the affinity isolation of human protein complexes expressed at near endogenous levels.

Authors:  Michal Domanski; Kelly Molloy; Hua Jiang; Brian T Chait; Michael P Rout; Torben Heick Jensen; John LaCava
Journal:  Biotechniques       Date:  2012-05       Impact factor: 1.993

2.  Targeted mutation reveals a central role for SR-BI in hepatic selective uptake of high density lipoprotein cholesterol.

Authors:  M L Varban; F Rinninger; N Wang; V Fairchild-Huntress; J H Dunmore; Q Fang; M L Gosselin; K L Dixon; J D Deeds; S L Acton; A R Tall; D Huszar
Journal:  Proc Natl Acad Sci U S A       Date:  1998-04-14       Impact factor: 11.205

3.  A sensitive and rapid assay for homologous recombination in mosquito cells: impact of vector topology and implications for gene targeting.

Authors:  P Eggleston; Y Zhao
Journal:  BMC Genet       Date:  2001-12-17       Impact factor: 2.797
  3 in total

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