Literature DB >> 7763229

Peroxynitrite causes DNA nicks in plasmid pBR322.

M G Salgo1, K Stone, G L Squadrito, J R Battista, W A Pryor.   

Abstract

Peroxynitrite causes single-strand breaks in pBR322 supercoiled DNA as evidenced by agarose gel electrophoresis analysis. The effect of three free radical scavengers, namely mannitol, benzoate and dimethylsulfoxide, were studied. Mannitol failed to protect DNA from damage by peroxynitrite while benzoate and dimethylsulfoxide amplified the damage. These results suggest the damage caused by peroxynitrite alone is not mediated by free radicals since typical free radical scavengers fail to prevent the damage.

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Year:  1995        PMID： 7763229     DOI： 10.1006/bbrc.1995.1759

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  21 in total

1.  DNA damage by peroxynitrite characterized with DNA repair enzymes.

Authors:  B Epe; D Ballmaier; I Roussyn; K Briviba; H Sies
Journal:  Nucleic Acids Res       Date:  1996-11-01       Impact factor: 16.971

2.  Attenuation of oxidation and nitration reactions of peroxynitrite by selenomethionine, selenocystine and ebselen.

Authors:  K Briviba; I Roussyn; V S Sharov; H Sies
Journal:  Biochem J       Date:  1996-10-01       Impact factor: 3.857

Review 3.  Pathophysiological roles of peroxynitrite in circulatory shock.

Authors:  Csaba Szabó; Katalin Módis
Journal:  Shock       Date:  2010-09       Impact factor: 3.454

Review 4.  Pathophysiological Role of Peroxynitrite Induced DNA Damage in Human Diseases: A Special Focus on Poly(ADP-ribose) Polymerase (PARP).

Authors:  Badar Ul Islam; Safia Habib; Parvez Ahmad; Shaziya Allarakha; Asif Ali
Journal:  Indian J Clin Biochem       Date:  2015-01-20

5.  The extracytoplasmic function sigma factor σS protects against both intracellular and extracytoplasmic stresses in Staphylococcus aureus.

Authors:  Halie K Miller; Ronan K Carroll; Whittney N Burda; Christina N Krute; Jessica E Davenport; Lindsey N Shaw
Journal:  J Bacteriol       Date:  2012-06-08       Impact factor: 3.490

Review 6.  Glutamate receptors, neurotoxicity and neurodegeneration.

Authors:  Anthony Lau; Michael Tymianski
Journal:  Pflugers Arch       Date:  2010-03-14       Impact factor: 3.657

7.  Tempol protection of spinal cord mitochondria from peroxynitrite-induced oxidative damage.

Authors:  Yiqin Xiong; Indrapal N Singh; Edward D Hall
Journal:  Free Radic Res       Date:  2009-06

8.  (-)-Epigallocatechin gallate, a polyphenolic tea antioxidant, inhibits peroxynitrite-mediated formation of 8-oxodeoxyguanosine and 3-nitrotyrosine.

Authors:  E S Fiala; R S Sodum; M Bhattacharya; H Li
Journal:  Experientia       Date:  1996-09-15

9.  Chemical-biological fingerprinting: probing the properties of DNA lesions formed by peroxynitrite.

Authors:  Sarah Delaney; James C Delaney; John M Essigmann
Journal:  Chem Res Toxicol       Date:  2007-10-18       Impact factor: 3.739

Review 10.  Role of oxidative stress and nitric oxide in atherothrombosis.

Authors:  Edith Lubos; Diane E Handy; Joseph Loscalzo
Journal:  Front Biosci       Date:  2008-05-01
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