Literature DB >> 7761853

Fibroblasts as efficient antigen-presenting cells in lymphoid organs.

T M Kündig1, M F Bachmann, C DiPaolo, J J Simard, M Battegay, H Lother, A Gessner, K Kühlcke, P S Ohashi, H Hengartner.   

Abstract

Only so-called "professional" antigen-presenting cells (APCs) of hematopoietic origin are believed capable of inducing T lymphocyte responses. However, fibroblasts transfected with viral proteins directly induced antiviral cytotoxic T lymphocyte responses in vivo, without involvement of host APCs. Fibroblasts induced T cells only in the milieu of lymphoid organs. Thus, antigen localization affects self-nonself discrimination and cell-based vaccine strategies.

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Year:  1995        PMID： 7761853     DOI： 10.1126/science.7761853

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  73 in total

1.  Recombinant expression of lymphocytic choriomeningitis virus strain WE glycoproteins: a single amino acid makes the difference.

Authors:  W R Beyer; H Miletic; W Ostertag; D von Laer
Journal:  J Virol       Date:  2001-01       Impact factor: 5.103

2.  Macrophages escape inhibition of major histocompatibility complex class I-dependent antigen presentation by cytomegalovirus.

Authors:  H Hengel; U Reusch; G Geginat; R Holtappels; T Ruppert; E Hellebrand; U H Koszinowski
Journal:  J Virol       Date:  2000-09       Impact factor: 5.103

3.  Distinct roles of adenovirus vector-transduced dendritic cells, myoblasts, and endothelial cells in mediating an immune response against a transgene product.

Authors:  Stéphanie Mercier; Hanne Gahéry-Segard; Martine Monteil; Renée Lengagne; Jean-Gérard Guillet; Marc Eloit; Caroline Denesvre
Journal:  J Virol       Date:  2002-03       Impact factor: 5.103

Review 4.  Targeting stroma to treat cancers.

Authors:  Boris Engels; Donald A Rowley; Hans Schreiber
Journal:  Semin Cancer Biol       Date:  2011-12-24       Impact factor: 15.707

5.  Intraoperative subcutaneous or intrasplenic vaccination with modified autologous tumor cells leads to enhanced survival in a mouse tumor model.

Authors:  Arne Dietrich; Christoph Stockmar; Gabriela Aust; Susan Endesfelder; Anke Guetz; Ulrich Sack; Manfred Schoenfelder; Johann Hauss
Journal:  J Cancer Res Clin Oncol       Date:  2006-01-04       Impact factor: 4.553

6.  Direct stimulation of T lymphocytes by immunosomes: virus-like particles decorated with T cell receptor/CD3 ligands plus costimulatory molecules.

Authors:  Sophia V Derdak; Hans J Kueng; Victoria M Leb; Alina Neunkirchner; Klaus G Schmetterer; Edith Bielek; Otto Majdic; Walter Knapp; Brian Seed; Winfried F Pickl
Journal:  Proc Natl Acad Sci U S A       Date:  2006-08-21       Impact factor: 11.205

7.  Presentation of Toxoplasma gondii antigens via the endogenous major histocompatibility complex class I pathway in nonprofessional and professional antigen-presenting cells.

Authors:  Florence Dzierszinski; Marion Pepper; Jason S Stumhofer; David F LaRosa; Emma H Wilson; Laurence A Turka; Sandra K Halonen; Christopher A Hunter; David S Roos
Journal:  Infect Immun       Date:  2007-09-10       Impact factor: 3.441

Review 8.  Involvement of CD80 in the generation of CD4+ cytotoxic T cells.

Authors:  D Mauri; W J Pichler
Journal:  Immunol Res       Date:  1996       Impact factor: 2.829

Review 9.  New routes for allergen immunotherapy.

Authors:  Pål Johansen; Seraina von Moos; Deepa Mohanan; Thomas M Kündig; Gabriela Senti
Journal:  Hum Vaccin Immunother       Date:  2012-10-01       Impact factor: 3.452

10.  Lymph node-targeted immunotherapy mediates potent immunity resulting in regression of isolated or metastatic human papillomavirus-transformed tumors.

Authors:  Kent A Smith; Brenna L Meisenburg; Victor L Tam; Robb R Pagarigan; Raymond Wong; Diljeet K Joea; Liz Lantzy; Mayra A Carrillo; Todd M Gross; Uriel M Malyankar; Chih-Sheng Chiang; Diane M Da Silva; Thomas M Kündig; W Martin Kast; Zhiyong Qiu; Adrian Bot
Journal:  Clin Cancer Res       Date:  2009-09-29       Impact factor: 12.531
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