| Literature DB >> 7760984 |
S Boyce1, C C Chan, R Gordon, C S Li, I W Rodger, J K Webb, N M Rupniak, R G Hill.
Abstract
L-745,337 [5-methanesulphonamido-6-(2,4-difluorothiophenyl)-1-indan one] a selective cyclooxygenase-2 inhibitor reversed hyperalgesia induced by carrageenan in rats without causing gastric ulceration at doses 100 times those causing antinociception. In contrast, piroxicam and indomethacin produced ulcerations at antinociceptive doses. These findings demonstrate that L-745,337 possesses antinociceptive activity but has a reduced liability for gastric ulceration.Entities:
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Year: 1994 PMID： 7760984 DOI： 10.1016/0028-3908(94)90137-6
Source DB: PubMed Journal: Neuropharmacology ISSN： 0028-3908 Impact factor: 5.250