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Literature DB >> 9058309

Nonsteroidal anti-inflammatory drug-induced gastrointestinal toxicity: new insights into an old problem.

Abstract

Nonsteroidal anti-inflammatory drugs are widely used for the treatment of chronic arthropathies, but their gastrointestinal damage remains a significant limitation to their use. In this review, the pathogenic mechanisms through which these drugs are believed to cause gastrointestinal damage are outlined. A better understanding of the pathogenesis of gastric and intestinal injury has resulted in novel strategies that are being employed to develop nonsteroidal anti-inflammatory drugs that do not have significant adverse effects on the gastrointestinal tract.

Entities: Disease

Mesh：

Substances：

Year: 1997 PMID： 9058309 DOI： 10.1007/bf01213310

Source DB: PubMed Journal: J Gastroenterol ISSN： 0944-1174 Impact factor: 7.527

82 in total

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Journal: Pharmacol Rev Date: 1955-09 Impact factor: 25.468

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Authors: R Upadhyay; H I Torley; A W McKinlay; R D Sturrock; R I Russell
Journal: Ann Rheum Dis Date: 1990-06 Impact factor: 19.103

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Journal: Nature Date: 1995-11-23 Impact factor: 49.962

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Authors: S N Elliott; W McKnight; G Cirino; J L Wallace
Journal: Gastroenterology Date: 1995-08 Impact factor: 22.682

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Authors: J F Brown; A C Keates; P J Hanson; B J Whittle
Journal: Am J Physiol Date: 1993-09

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Journal: Cell Date: 1995-11-03 Impact factor: 41.582

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Authors: S G Morham; R Langenbach; C D Loftin; H F Tiano; N Vouloumanos; J C Jennette; J F Mahler; K D Kluckman; A Ledford; C A Lee; O Smithies
Journal: Cell Date: 1995-11-03 Impact factor: 41.582

8. Gastrointestinal damage associated with the use of nonsteroidal antiinflammatory drugs.

Authors: M C Allison; A G Howatson; C J Torrance; F D Lee; R I Russell
Journal: N Engl J Med Date: 1992-09-10 Impact factor: 91.245

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Authors: H Asako; P Kubes; J Wallace; R E Wolf; D N Granger
Journal: Gastroenterology Date: 1992-07 Impact factor: 22.682

10. Mast cells as a source of both preformed and immunologically inducible TNF-alpha/cachectin.

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Journal: Nature Date: 1990-07-19 Impact factor: 49.962

13 in total

Review 1. Epidemiology of perforated colonic diverticular disease.

Authors: C R Morris; I M Harvey; W S L Stebbings; C T M Speakman; H J Kennedy; A R Hart
Journal: Postgrad Med J Date: 2002-11 Impact factor: 2.401

Review 2. A Double Whammy: Targeting Both Fatty Acid Amide Hydrolase (FAAH) and Cyclooxygenase (COX) To Treat Pain and Inflammation.

Authors: Rita Scarpelli; Oscar Sasso; Daniele Piomelli
Journal: ChemMedChem Date: 2015-10-21 Impact factor: 3.466

3. Strictures, diaphragms, erosions or ulcerations of ischemic type in the colon should always prompt consideration of nonsteroidal anti-inflammatory drug-induced lesions.

Authors: Manfred Stolte; Diana Karimi; Michael Vieth; Hildegard Volkholz; Klaus Dirschmid; Sigrid Rappel; Birgit Bethke
Journal: World J Gastroenterol Date: 2005-10-07 Impact factor: 5.742

Review 4. Gastrointestinal effects of aspirin.

Authors: Carlos Sostres; Angel Lanas
Journal: Nat Rev Gastroenterol Hepatol Date: 2011-06-07 Impact factor: 46.802

5. Effects of pentosan polysulfate in osteoarthritis of the knee: A randomized, double-blind, placebo-controlled pilot study.

Authors: Peter Ghosh; Jack Edelman; Lyn March; Margaret Smith
Journal: Curr Ther Res Clin Exp Date: 2005-11

6. Changing prevalence of Helicobacter pylori infection and peptic ulcer among dyspeptic Sardinian patients.

Authors: Maria Pina Dore; Giuseppina Marras; Chiara Rocchi; Sara Soro; Maria Francesca Loria; Gabrio Bassotti; David Y Graham; Hoda M Malaty; Giovanni M Pes
Journal: Intern Emerg Med Date: 2015-03-05 Impact factor: 3.397

Review 7. Time dependent risk of gastrointestinal complications induced by non-steroidal anti-inflammatory drug use: a consensus statement using a meta-analytic approach.

Authors: F Richy; O Bruyere; O Ethgen; V Rabenda; G Bouvenot; M Audran; G Herrero-Beaumont; A Moore; R Eliakim; M Haim; J-Y Reginster
Journal: Ann Rheum Dis Date: 2004-07 Impact factor: 19.103

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Authors: Urs A Boelsterli
Journal: Drug Saf Date: 2002 Impact factor: 5.606

9. Potent multitarget FAAH-COX inhibitors: Design and structure-activity relationship studies.

Authors: Marco Migliore; Damien Habrant; Oscar Sasso; Clara Albani; Sine Mandrup Bertozzi; Andrea Armirotti; Daniele Piomelli; Rita Scarpelli
Journal: Eur J Med Chem Date: 2015-12-23 Impact factor: 6.514

10. Orengedokuto and berberine improve indomethacin-induced small intestinal injury via adenosine.

Authors: Yoko Watanabe-Fukuda; Masahiro Yamamoto; Naoko Miura; Masato Fukutake; Atsushi Ishige; Rui Yamaguchi; Masao Nagasaki; Ayumu Saito; Seiya Imoto; Satoru Miyano; Junzo Takeda; Kenji Watanabe
Journal: J Gastroenterol Date: 2009-03-25 Impact factor: 7.527