Literature DB >> 7760431

Effects of isoprenaline, phenylephrine on heart and influence of nifedipine on these effects.

Y X Ma1, S Yu, H Y Zhao.   

Abstract

In a perfused isovolumetrically contracting rat heart model, the effects of isoprenaline (IPN) and phenylephrine (PE) on myocardial contraction and relaxation were investigated, and the influence of nifedipine on these effects was studied. Both IPN and PE increased the myocardial contraction and improved its relaxation, but some differences existed. Nifedipine (10 nmol/L) substantially inhibited the PE-mediated inotropic effect, but in case of IPN-mediated inotropic ones, it did not. It was assumed that there may be various types of slow channels, one was activated by IPN, and the other, by PE.

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Year:  1994        PMID： 7760431     DOI： 10.1007/BF02897671

Source DB:  PubMed          Journal:  J Tongji Med Univ        ISSN： 0257-716X


  6 in total

1.  Evidence for alpha 1-adrenoceptor-mediated increase of inositol trisphosphate in the human heart.

Authors:  C Kohl; W Schmitz; H Scholz; J Scholz; M Tóth; V Döring; P Kalmár
Journal:  J Cardiovasc Pharmacol       Date:  1989-02       Impact factor: 3.105

2.  [On the effect of various sympathomimetic amines on contractility and Ca-45-uptake of isolated guinea pig auricles].

Authors:  H Reuter; U Wollert
Journal:  Naunyn Schmiedebergs Arch Exp Pathol Pharmakol       Date:  1967-09-15

3.  [On the relations of effects of adrenaline, a beta-adrenolytic and quinidine on the contraction power and calcium metabolism of the guinea pig atrium].

Authors:  K H Rahn; H Reuter
Journal:  Naunyn Schmiedebergs Arch Exp Pathol Pharmakol       Date:  1966

4.  Inotropic stimuli and systolic transmembrane calcium flow in depolarized guinea-pig atria.

Authors:  P T Thyrum
Journal:  J Pharmacol Exp Ther       Date:  1974-01       Impact factor: 4.030

5.  Inositol trisphosphate does not release Ca2+ from permeabilized cardiac myocytes and sarcoplasmic reticulum.

Authors:  M A Movsesian; A P Thomas; M Selak; J R Williamson
Journal:  FEBS Lett       Date:  1985-06-17       Impact factor: 4.124

6.  Alpha-1 adrenoceptor-mediated positive inotropic effect and inositol trisphosphate increase in mammalian heart.

Authors:  J Scholz; B Schaefer; W Schmitz; H Scholz; M Steinfath; M Lohse; U Schwabe; J Puurunen
Journal:  J Pharmacol Exp Ther       Date:  1988-04       Impact factor: 4.030
  6 in total

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