Literature DB >> 2468965

Evidence for alpha 1-adrenoceptor-mediated increase of inositol trisphosphate in the human heart.

C Kohl1, W Schmitz, H Scholz, J Scholz, M Tóth, V Döring, P Kalmár.   

Abstract

In human-isolated ventricular myocardium the alpha 1-adrenoceptor agonist phenylephrine has a positive inotropic effect but its mechanism is largely unknown. We studied the effects of phenylephrine in trabeculae isolated from three nonfailing human hearts. We found that the force of contraction rose concentration-dependently (1-300 mumol/L), maximally, to about 235% of control (at 100 mumol/L). The inositol phosphates were increased to 195-262%, whereas the phosphatidylinositol phosphate and phosphatidylinositol bisphosphate decreased to 69-73% of control. The present results suggest that the alpha 1-adrenoceptor-mediated increase in inositol trisphosphate and the positive inotropic effect may be causally related in the normal human heart.

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Year:  1989        PMID： 2468965     DOI： 10.1097/00005344-198902000-00023

Source DB:  PubMed          Journal:  J Cardiovasc Pharmacol        ISSN： 0160-2446            Impact factor:   3.105


  13 in total

Review 1.  On the mechanism of positive inotropic effects of alpha-adrenoceptor agonists.

Authors:  W Schmitz; C Kohl; J Neumann; H Scholz; J Scholz
Journal:  Basic Res Cardiol       Date:  1989       Impact factor: 17.165

2.  Effects of carbachol and (-)-N6-phenylisopropyladenosine on myocardial inositol phosphate content and force of contraction.

Authors:  C Kohl; B Linck; W Schmitz; H Scholz; J Scholz; M Tóth
Journal:  Br J Pharmacol       Date:  1990-12       Impact factor: 8.739

3.  1,2-diacylglycerol content in myocardium from spontaneously hypertensive rats during the development of hypertension.

Authors:  J Kondo; Y Yamada; K Okumura; H Hashimoto; T Ito; T Satake
Journal:  Basic Res Cardiol       Date:  1990 Sep-Oct       Impact factor: 17.165

4.  Norepinephrine-induced 1,2-diacylglycerol accumulation and change in its fatty acid composition in the isolated perfused rat heart.

Authors:  K Okumura; Y Shirai; J Kondo; H Hashimoto; T Ito; K Ogawa
Journal:  Mol Cell Biochem       Date:  1990-03-27       Impact factor: 3.396

5.  Phosphoinositide kinases in rat heart sarcolemma: biochemical properties and regulation by calcium.

Authors:  N Mesaeli; J M Lamers; V Panagia
Journal:  Mol Cell Biochem       Date:  1992-11-18       Impact factor: 3.396

6.  Increased calcium release from sarcoplasmic reticulum stimulated by inositol trisphosphate in spontaneously hypertensive rat heart cells.

Authors:  H Kawaguchi; H Sano; H Okada; K Iizuka; H Okamoto; T Kudo; T Murakami; A Kitabatake
Journal:  Mol Cell Biochem       Date:  1993-02-17       Impact factor: 3.396

7.  Effects of isoprenaline, phenylephrine on heart and influence of nifedipine on these effects.

Authors:  Y X Ma; S Yu; H Y Zhao
Journal:  J Tongji Med Univ       Date:  1994

8.  Comparison of the positive inotropic effects of serotonin, histamine, angiotensin II, endothelin and isoprenaline in the isolated human right atrium.

Authors:  H R Zerkowski; A Broede; K Kunde; S Hillemann; E Schäfer; M Vogelsang; M C Michel; O E Brodde
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1993-04       Impact factor: 3.000

9.  Reduced alpha 1- and beta 2-adrenoceptor-mediated positive inotropic effects in human end-stage heart failure.

Authors:  M Steinfath; W Danielsen; H von der Leyen; U Mende; W Meyer; J Neumann; M Nose; T Reich; W Schmitz; H Scholz
Journal:  Br J Pharmacol       Date:  1992-02       Impact factor: 8.739

10.  Effects of benzyltetrahydropalmatine on delayed after depolarization and triggered activity and on His-bundle electrogram and ECG in animal experiment.

Authors:  W X Yao; M X Jiang; G J Xia; W Z Zeng
Journal:  J Tongji Med Univ       Date:  1991
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