E Casalini1, M S Sfondrini, E Fossali. 1. Servizio di Radiodiagnostica e di Radioterapia, Radiologia IOG, Istituti Clinici di Perfezionamento, Milan, Italy.
Abstract
RATIONALE AND OBJECTIVES: Two percent of children have hypertension. For those younger than 10 years of age, there is a high probability that hypertension is secondary. The purpose of this study was to evaluate the merits of percutaneous transluminal angioplasty (PTA) in the treatment of childhood renovascular hypertension (RVH) in light of the results previously obtained by the authors and to evaluate their stability at 2-year follow-up. METHODS: The positive response of peripheral renin plasma levels to a single dose of captopril was used as a criterion for selecting 36 patients between 4 and 15 years of age with renovascular hypertension. All underwent angiography; in most patients, PTA was performed in the same session. A 2-year follow-up study was conducted. RESULTS: In the 36 patients considered for RVH screening, PTA was successful in 34 of 36 patients (94%). Four of these patients had neurofibromatosis. The high success rate was confirmed in the 2-year follow-up study: 34 patients continue to be normotensive. CONCLUSIONS: Percutaneous transluminal angioplasty treatment of pediatric patients with hypertension has proved to be an effective and valuable method when the cause of renal artery stenosis is fibromuscular dysplasia, and the long-term results were sufficient to suggest the use of this technique in patients with neurofibromatosis as well.
RATIONALE AND OBJECTIVES: Two percent of children have hypertension. For those younger than 10 years of age, there is a high probability that hypertension is secondary. The purpose of this study was to evaluate the merits of percutaneous transluminal angioplasty (PTA) in the treatment of childhood renovascular hypertension (RVH) in light of the results previously obtained by the authors and to evaluate their stability at 2-year follow-up. METHODS: The positive response of peripheral renin plasma levels to a single dose of captopril was used as a criterion for selecting 36 patients between 4 and 15 years of age with renovascular hypertension. All underwent angiography; in most patients, PTA was performed in the same session. A 2-year follow-up study was conducted. RESULTS: In the 36 patients considered for RVH screening, PTA was successful in 34 of 36 patients (94%). Four of these patients had neurofibromatosis. The high success rate was confirmed in the 2-year follow-up study: 34 patients continue to be normotensive. CONCLUSIONS: Percutaneous transluminal angioplasty treatment of pediatric patients with hypertension has proved to be an effective and valuable method when the cause of renal artery stenosis is fibromuscular dysplasia, and the long-term results were sufficient to suggest the use of this technique in patients with neurofibromatosis as well.
Authors: J Humbert; G Roussey-Kesler; P Guerin; T LeFrançois; J Connault; A Chenouard; K Warin-Fresse; R Salomon; A Bruel; E Allain-Launay Journal: Eur J Pediatr Date: 2014-06-24 Impact factor: 3.183
Authors: Jonathan L Eliason; Dawn M Coleman; Enrique Criado; David B Kershaw; Neal B Blatt; David M Williams; Narasimham L Dasika; Kyung J Cho; James C Stanley Journal: Pediatr Nephrol Date: 2015-12-01 Impact factor: 3.714