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Literature DB >> 7758112

A targeting signal in VAMP regulating transport to synaptic vesicles.

E Grote¹, J C Hao, M K Bennett, R B Kelly.

Abstract

VAMP is a synaptic vesicle membrane protein required for fusion. Synaptic vesicle targeting was measured for mutants of an epitope-tagged form of VAMP in transfected PC12 cells. A signal within a predicted amphipathic alpha helix is essential for targeting to synaptic vesicles. Cellubrevin, a nonneural VAMP homolog, contains this signal and is also targeted to synaptic vesicles. Amino acid substitutions within the synaptic vesicle targeting signal either enhance or inhibit sorting of VAMP to synaptic vesicles, but do not affect the ability of VAMP to form complexes with syntaxin and SNAP-25.

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Year: 1995 PMID： 7758112 DOI： 10.1016/0092-8674(95)90079-9

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

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Cited

53 in total

1. Sorting to synaptic-like microvesicles from early and late endosomes requires overlapping but not identical targeting signals.

Authors: A D Blagoveshchenskaya; D F Cutler
Journal: Mol Biol Cell Date: 2000-05 Impact factor: 4.138

2. Specific retrieval of the exocytic SNARE Snc1p from early yeast endosomes.

Authors: M J Lewis; B J Nichols; C Prescianotto-Baschong; H Riezman; H R Pelham
Journal: Mol Biol Cell Date: 2000-01 Impact factor: 4.138

3. The SNARE Vti1a-beta is localized to small synaptic vesicles and participates in a novel SNARE complex.

Authors: W Antonin; D Riedel; G F von Mollard
Journal: J Neurosci Date: 2000-08-01 Impact factor: 6.167

Review 4. Signals involved in targeting membrane proteins to synaptic vesicles.

Authors: Vania F Prado; Marco A M Prado
Journal: Cell Mol Neurobiol Date: 2002-12 Impact factor: 5.046

5. Yeast exocytic v-SNAREs confer endocytosis.

Authors: S Gurunathan; D Chapman-Shimshoni; S Trajkovic; J E Gerst
Journal: Mol Biol Cell Date: 2000-10 Impact factor: 4.138

6. The zinc transporter ZnT3 interacts with AP-3 and it is preferentially targeted to a distinct synaptic vesicle subpopulation.

Authors: Gloria Salazar; Rachal Love; Erica Werner; Michele M Doucette; Su Cheng; Allan Levey; Victor Faundez
Journal: Mol Biol Cell Date: 2003-12-02 Impact factor: 4.138

A targeting signal in VAMP regulating transport to synaptic vesicles.

1. Sorting to synaptic-like microvesicles from early and late endosomes requires overlapping but not identical targeting signals.

2. Specific retrieval of the exocytic SNARE Snc1p from early yeast endosomes.

3. The SNARE Vti1a-beta is localized to small synaptic vesicles and participates in a novel SNARE complex.

Review 4. Signals involved in targeting membrane proteins to synaptic vesicles.

5. Yeast exocytic v-SNAREs confer endocytosis.

6. The zinc transporter ZnT3 interacts with AP-3 and it is preferentially targeted to a distinct synaptic vesicle subpopulation.

7. A coiled coil trigger site is essential for rapid binding of synaptobrevin to the SNARE acceptor complex.

8. Factors regulating the abundance and localization of synaptobrevin in the plasma membrane.

9. A flexible protein linker improves the function of epitope-tagged proteins in Saccharomyces cerevisiae.

10. Roles of BLOC-1 and adaptor protein-3 complexes in cargo sorting to synaptic vesicles.