| Literature DB >> 7757470 |
R Godbout1, P Jelenic, C Labrie, M Schmitt, J J Bourguignon.
Abstract
Gamma-hydroxybutyrate (GHB) at low doses (5-10 mg/kg i.p.) increased and at high doses (160-320 mg/kg i.p.) decreased the spontaneous firing rate of prefrontal cortex (PFC) neurons recorded in urethane-anesthetized rats. Only excitations were blocked by NCS-382, a specific GHB receptor antagonist; this suggests that the excitatory effect of low doses of GHB is mediated by a GHB receptor whereas the inhibitory effect of high doses of GHB involves a more complex mechanism.Entities:
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Year: 1995 PMID： 7757470 DOI： 10.1016/0006-8993(94)01461-p
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252