Literature DB >> 7755600

Carbohydrate composition of serum transferrin isoforms from patients with high alcohol consumption.

E Landberg1, P Påhlsson, A Lundblad, A Arnetorp, J O Jeppsson.   

Abstract

Normal human serum transferrin is present in several isoforms, due to differences in glycosylation. Transferrin has two potential glycosylation sites, both normally occupied by oligosaccharide chains. Two of the transferrin isoforms, called carbohydrate deficient transferrin, are specifically increased in patients with high alcohol consumption. In this study, five isoforms of transferrin were isolated from patients with high alcohol consumption. N-linked glycans were released by N-glycosidase digestion and were radioactively labeled by NaB3H4 reduction. The purified oligosaccharides were analyzed by high-pH anion-exchange chromatography, and the carbohydrate composition of each individual transferrin isoform was determined. The carbohydrate deficient transferrin isoforms were found to lack one or both of their entire carbohydrate chains.

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Year:  1995        PMID： 7755600     DOI： 10.1006/bbrc.1995.1656

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  8 in total

1.  The identification of abnormal glycoforms of serum transferrin in carbohydrate deficient glycoprotein syndrome type I by capillary zone electrophoresis.

Authors:  O Iourin; T S Mattu; N Mian; G Keir; B Winchester; R A Dwek; P M Rudd
Journal:  Glycoconj J       Date:  1996-12       Impact factor: 2.916

2.  Determination of glycan structures and molecular masses of the glycovariants of serum transferrin from a patient with carbohydrate deficient syndrome type II.

Authors:  B Coddeville; H Carchon; J Jaeken; G Briand; G Spik
Journal:  Glycoconj J       Date:  1998-03       Impact factor: 2.916

Review 3.  Chemoenzymatic method for glycomics: Isolation, identification, and quantitation.

Authors:  Shuang Yang; Abigail Rubin; Shadi Toghi Eshghi; Hui Zhang
Journal:  Proteomics       Date:  2015-11-06       Impact factor: 3.984

4.  Square-wave voltammetry assays for glycoproteins on nanoporous gold.

Authors:  Binod Pandey; Jay K Bhattarai; Papapida Pornsuriyasak; Kohki Fujikawa; Rosa Catania; Alexei V Demchenko; Keith J Stine
Journal:  J Electroanal Chem (Lausanne)       Date:  2014-03-15       Impact factor: 4.464

5.  Glycosylation of alpha1-acid glycoprotein in inflammatory disease: analysis by high-pH anion-exchange chromatography and concanavalin A crossed affinity immunoelectrophoresis.

Authors:  I Rydén; G Skude; A Lundblad; P Påhlsson
Journal:  Glycoconj J       Date:  1997-06       Impact factor: 2.916

6.  Relationship of Abnormal Chromatographic Pattern for Carbohydrate-Deficient Transferrin with Severe Liver Disease.

Authors:  Scott H Stewart; Adrian Reuben; Raymond F Anton
Journal:  Alcohol Alcohol       Date:  2016-10-07       Impact factor: 2.826

7.  Analytical performance of immobilized pronase for glycopeptide footprinting and implications for surpassing reductionist glycoproteomics.

Authors:  Eric D Dodds; Richard R Seipert; Brian H Clowers; J Bruce German; Carlito B Lebrilla
Journal:  J Proteome Res       Date:  2009-02       Impact factor: 4.466

8.  Glycosylation defects underlying fetal alcohol spectrum disorder: a novel pathogenetic model. "When the wine goes in, strange things come out" - S.T. Coleridge, The Piccolomini.

Authors:  M Binkhorst; S B Wortmann; S Funke; T Kozicz; R A Wevers; E Morava
Journal:  J Inherit Metab Dis       Date:  2011-12-02       Impact factor: 4.982
  8 in total

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