PURPOSE: To describe the radiographic and computed tomographic (CT) findings in seven patients with nonspecific interstitial pneumonia with fibrosis (NIP). MATERIALS AND METHODS: NIP was proved pathologically in all patients. Findings at radiography and initial and 1-15-month follow-up CT were reviewed. RESULTS: The predominant radiographic abnormalities were areas of patchy parenchymal opacification present bilaterally in the middle and lower lung zones in six patients; in one patient, the chest radiograph depicted no abnormality. The most common finding observed on initial thin-section CT scans was bilateral, patchy areas of ground-glass attenuation present alone or with areas of consolidation in five patients (71%) or irregular lines in two (29%). At follow-up CT, the initial parenchymal abnormalities had resolved completely in three patients, improved in another three, and persisted in one. CONCLUSION: Bilateral patchy areas of opacity depicted radiographically and good clinical response to treatment may differentiate NIP from other interstitial pneumonias.
PURPOSE: To describe the radiographic and computed tomographic (CT) findings in seven patients with nonspecific interstitial pneumonia with fibrosis (NIP). MATERIALS AND METHODS: NIP was proved pathologically in all patients. Findings at radiography and initial and 1-15-month follow-up CT were reviewed. RESULTS: The predominant radiographic abnormalities were areas of patchy parenchymal opacification present bilaterally in the middle and lower lung zones in six patients; in one patient, the chest radiograph depicted no abnormality. The most common finding observed on initial thin-section CT scans was bilateral, patchy areas of ground-glass attenuation present alone or with areas of consolidation in five patients (71%) or irregular lines in two (29%). At follow-up CT, the initial parenchymal abnormalities had resolved completely in three patients, improved in another three, and persisted in one. CONCLUSION: Bilateral patchy areas of opacity depicted radiographically and good clinical response to treatment may differentiate NIP from other interstitial pneumonias.
Authors: K R Flaherty; E L Thwaite; E A Kazerooni; B H Gross; G B Toews; T V Colby; W D Travis; J A Mumford; S Murray; A Flint; J P Lynch; F J Martinez Journal: Thorax Date: 2003-02 Impact factor: 9.139
Authors: Z A Aziz; A U Wells; D M Hansell; G A Bain; S J Copley; S R Desai; S M Ellis; F V Gleeson; S Grubnic; A G Nicholson; S P G Padley; K S Pointon; J H Reynolds; R J H Robertson; M B Rubens Journal: Thorax Date: 2004-06 Impact factor: 9.139