Literature DB >> 7753932

Conformational analysis and biological activity of leptocarpin and leptocarpin acetate.

R Martínez, V Kesternich, E Gutierrez, H Dölz, H Mansilla.   

Abstract

This paper deals with the conformational study in solution of leptocarpin, a germacranolide with the heliangolide structure isolated from Leptocarpha rivularis D.C. The results obtained agree with the single crystal X-ray diffraction studies. Leptocarpin and leptocarpin acetate show 50% inhibition of [35S]-methionine uptake without affecting the (methyl-3H)thymidine and (5,6-3H)uridine incorporation, when assayed in HeLa cells.

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Year:  1995        PMID: 7753932     DOI: 10.1055/s-2006-958048

Source DB:  PubMed          Journal:  Planta Med        ISSN: 0032-0943            Impact factor:   3.352


  2 in total

1.  Leptocarpin Suppresses Proliferation, Migration, and Invasion of Human Osteosarcoma by Targeting Type-1 Insulin-Like Growth Factor Receptor (IGF-1R).

Authors:  Shao-Wei Zheng; Wen-Guo Wan; Hai-Xiong Miao; Rui Tang; Bin Wang; Qi-Zhi Huang; Wei-le Liu; Jian-Ping Zheng; Chu-Qun Chen; Hao-Bo Zhong; Sheng-Fa Li; Chun-Han Sun
Journal:  Med Sci Monit       Date:  2017-08-27

2.  Phytochemical Profiling and Assessment of Anticancer Activity of Leptocarpha rivularis Extracts Obtained from In Vitro Cultures.

Authors:  Julia Rubio; Guisselle Arias; Christian Robles-Kelly; Evelyn Silva-Moreno; Luis Espinoza; Héctor Carrasco; Andrés F Olea
Journal:  Plants (Basel)       Date:  2022-02-18
  2 in total

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