Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Physical mapping, cloning, and identification of genes within a 500-kb region containing BRCA1.

Literature DB >> 7753812

Physical mapping, cloning, and identification of genes within a 500-kb region containing BRCA1.

M A Brown¹, K A Jones, H Nicolai, M Bonjardim, D Black, R McFarlane, P de Jong, J P Quirk, H Lehrach, E Solomon.

Abstract

BRCA1 is a breast/ovarian cancer susceptibility gene on human chromosome 17q21. We describe a complete and detailed physical map of a 500-kb region of genomic DNA containing the BRCA1 gene and the partial cloning in phage P1 artificial chromosomes. Approximately 70 exons were isolated from this region, 11 of which were components of the BRCA1 gene. Analysis of the other exons revealed a rho-related G protein and the interferon-induced leucine-zipper protein IFP-35.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1995 PMID： 7753812 PMCID： PMC41944 DOI： 10.1073/pnas.92.10.4362

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

12 in total

1. Genomic organization and DNA sequences of human 17 beta-hydroxysteroid dehydrogenase genes and flanking regions. Localization of multiple Alu sequences and putative cis-acting elements.

Authors: H Peltoketo; V Isomaa; R Vihko
Journal: Eur J Biochem Date: 1992-10-01

Review 2. Regulation and function of the Rho subfamily of small GTPases.

Authors: C Nobes; A Hall
Journal: Curr Opin Genet Dev Date: 1994-02 Impact factor: 5.578

3. The detailed characterisation of a 400 kb cosmid walk in the BRCA1 region: identification and localisation of 10 genes including a dual-specificity phosphatase.

Authors: K A Jones; D M Black; M A Brown; B L Griffiths; H M Nicolai; J A Chambers; M Bonjardim; C F Xu; M Boyd; R McFarlane
Journal: Hum Mol Genet Date: 1994-11 Impact factor: 6.150

4. A new bacteriophage P1-derived vector for the propagation of large human DNA fragments.

Authors: P A Ioannou; C T Amemiya; J Garnes; P M Kroisel; H Shizuya; C Chen; M A Batzer; P J de Jong
Journal: Nat Genet Date: 1994-01 Impact factor: 38.330

5. Linkage of early-onset familial breast cancer to chromosome 17q21.

Authors: J M Hall; M K Lee; B Newman; J E Morrow; L A Anderson; B Huey; M C King
Journal: Science Date: 1990-12-21 Impact factor: 47.728

6. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1.

Authors: Y Miki; J Swensen; D Shattuck-Eidens; P A Futreal; K Harshman; S Tavtigian; Q Liu; C Cochran; L M Bennett; W Ding
Journal: Science Date: 1994-10-07 Impact factor: 47.728

7. Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. The Breast Cancer Linkage Consortium.

Authors: D F Easton; D T Bishop; D Ford; G P Crockford
Journal: Am J Hum Genet Date: 1993-04 Impact factor: 11.025

Review 6. IFP35 Is a Relevant Factor in Innate Immunity, Multiple Sclerosis, and Other Chronic Inflammatory Diseases: A Review.

Authors: Roberto De Masi; Stefania Orlando; Francesco Bagordo; Tiziana Grassi
Journal: Biology (Basel) Date: 2021-12-14

6 in total

Physical mapping, cloning, and identification of genes within a 500-kb region containing BRCA1.

1. Genomic organization and DNA sequences of human 17 beta-hydroxysteroid dehydrogenase genes and flanking regions. Localization of multiple Alu sequences and putative cis-acting elements.

Review 2. Regulation and function of the Rho subfamily of small GTPases.

3. The detailed characterisation of a 400 kb cosmid walk in the BRCA1 region: identification and localisation of 10 genes including a dual-specificity phosphatase.

4. A new bacteriophage P1-derived vector for the propagation of large human DNA fragments.

5. Linkage of early-onset familial breast cancer to chromosome 17q21.

6. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1.

7. Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. The Breast Cancer Linkage Consortium.

8. Exon amplification: a strategy to isolate mammalian genes based on RNA splicing.

9. A novel gene encoding a B-box protein within the BRCA1 region at 17q21.1.

10. High-density genetic map of the BRCA1 region of chromosome 17q12-q21.

1. Distinct BRCA1 rearrangements involving the BRCA1 pseudogene suggest the existence of a recombination hot spot.

2. Detecting genome wide haplotype sharing using SNP or microsatellite haplotype data.

3. Isolation of coding sequences from bovine cosmids by means of exon trapping.

4. Effect of BRCA2 sequence variants predicted to disrupt exonic splice enhancers on BRCA2 transcripts.

5. A de novo complete BRCA1 gene deletion identified in a Spanish woman with early bilateral breast cancer.

Review 6. IFP35 Is a Relevant Factor in Innate Immunity, Multiple Sclerosis, and Other Chronic Inflammatory Diseases: A Review.