Literature DB >> 7752835

Apparent partial remission of breast cancer in 'high risk' patients supplemented with nutritional antioxidants, essential fatty acids and coenzyme Q10.

K Lockwood1, S Moesgaard, T Hanioka, K Folkers.   

Abstract

Thirty-two typical patients with breast cancer, aged 32-81 years and classified 'high risk' because of tumor spread to the lymph nodes in the axilla, were studied for 18 months following an Adjuvant Nutritional Intervention in Cancer protocol (ANICA protocol). The nutritional protocol was added to the surgical and therapeutic treatment of breast cancer, as required by regulations in Denmark. The added treatment was a combination of nutritional antioxidants (Vitamin C: 2850 mg, Vitamin E: 2500 iu, beta-carotene 32.5 iu, selenium 387 micrograms plus secondary vitamins and minerals), essential fatty acids (1.2 g gamma linolenic acid and 3.5 g n-3 fatty acids) and Coenzyme Q10 (90 mg per day). The ANICA protocol is based on the concept of testing the synergistic effect of those categories of nutritional supplements, including vitamin Q10, previously having shown deficiency and/or therapeutic value as single elements in diverse forms of cancer, as cancer may be synergistically related to diverse biochemical dysfunctions and vitamin deficiencies. Biochemical markers, clinical condition, tumor spread, quality of life parameters and survival were followed during the trial. Compliance was excellent. The main observations were: (1) none of the patients died during the study period. (the expected number was four.) (2) none of the patients showed signs of further distant metastases. (3) quality of life was improved (no weight loss, reduced use of pain killers). (4) six patients showed apparent partial remission.

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Year:  1994        PMID: 7752835     DOI: 10.1016/0098-2997(94)90033-7

Source DB:  PubMed          Journal:  Mol Aspects Med        ISSN: 0098-2997


  11 in total

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Authors:  E Kaegi
Journal:  CMAJ       Date:  1998-06-02       Impact factor: 8.262

2.  Dietary supplementation with isolated soy protein reduces metastasis of mammary carcinoma cells in mice.

Authors:  Lin Yan; Donghua Li; John A Yee
Journal:  Clin Exp Metastasis       Date:  2002       Impact factor: 5.150

3.  Coenzyme q10 therapy.

Authors:  Juan Garrido-Maraver; Mario D Cordero; Manuel Oropesa-Ávila; Alejandro Fernández Vega; Mario de la Mata; Ana Delgado Pavón; Manuel de Miguel; Carmen Pérez Calero; Marina Villanueva Paz; David Cotán; José A Sánchez-Alcázar
Journal:  Mol Syndromol       Date:  2014-07

4.  Vitamin supplement use during breast cancer treatment and survival: a prospective cohort study.

Authors:  Sarah Nechuta; Wei Lu; Zhi Chen; Ying Zheng; Kai Gu; Hui Cai; Wei Zheng; Xiao Ou Shu
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2010-12-21       Impact factor: 4.254

Review 5.  [Potential of selenium in gynecologic oncology].

Authors:  A M Funke
Journal:  Med Klin (Munich)       Date:  1999-10-15

6.  Effect of vitamin E and human placenta cysteine peptidase inhibitor on expression of cathepsins B and L in implanted hepatoma Morris 5123 tumor model in Wistar rats.

Authors:  Tadeusz Sebzda; Piotr Hanczyc; Yousif Saleh; Bernice-F Akinpelumi; Maciej Siewinski; Jerzy Rudnicki
Journal:  World J Gastroenterol       Date:  2005-01-28       Impact factor: 5.742

7.  Cognitive dysfunction induced by chronic administration of common cancer chemotherapeutics in rats.

Authors:  Gregory W Konat; Michal Kraszpulski; Isaac James; Han-Ting Zhang; Jame Abraham
Journal:  Metab Brain Dis       Date:  2008-08-09       Impact factor: 3.584

8.  Effects of coenzyme Q10 supplementation on inflammation, angiogenesis, and oxidative stress in breast cancer patients: a systematic review and meta-analysis of randomized controlled- trials.

Authors:  Mina Alimohammadi; Ali Rahimi; Fatemeh Faramarzi; Monireh Golpour; Reza Jafari-Shakib; Reza Alizadeh-Navaei; Alireza Rafiei
Journal:  Inflammopharmacology       Date:  2021-05-18       Impact factor: 4.473

Review 9.  Antioxidants as precision weapons in war against cancer chemotherapy induced toxicity - Exploring the armoury of obscurity.

Authors:  Kanchanlata Singh; Mustansir Bhori; Yasar Arfat Kasu; Ganapathi Bhat; Thankamani Marar
Journal:  Saudi Pharm J       Date:  2017-12-19       Impact factor: 4.330

Review 10.  Nutraceuticals and Metastasis Development.

Authors:  Lara Saftić Martinović; Željka Peršurić; Krešimir Pavelić
Journal:  Molecules       Date:  2020-05-08       Impact factor: 4.411

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