Literature DB >> 7737237

Mouse liver microsomes (MLM) protect erythrocytes against trifluoperazine (TFP) induced and mechanical hemolysis which are due to TFP microsomal transformation and to the action of an unidentified water-soluble microsomal factor (UF).

N C Meirelles1, S V Malheiros, A C Ruggiero, I A Degterev.   

Abstract

Trifluoperazine (TFP), a phenothiazine derivative, produces either hemolysis or protection of erythrocytes under isosmotic conditions in a dose-dependent manner. The hemolytic effect of TFP is abolished in the presence of mouse liver microsomes (MLM) which is due, in part, to drug incorporation, transformation and a MLM enzyme driven metabolism. An unidentified water-soluble factor (or factors) derived from MLM has been found to protect erythrocytes against both mechanical and TFP-induced isosmotic hemolysis.

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Year:  1994        PMID： 7737237     DOI： 10.1007/BF03188862

Source DB:  PubMed          Journal:  Eur J Drug Metab Pharmacokinet        ISSN： 0378-7966            Impact factor:   2.441


  14 in total

1.  Protective effect of trifluoperazine on the mitochondrial damage induced by Ca2+ plus prooxidants.

Authors:  R S Pereira; A P Bertocchi; A E Vercesi
Journal:  Biochem Pharmacol       Date:  1992-11-03       Impact factor: 5.858

2.  THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. II. SOLUBILIZATION, PURIFICATION, AND PROPERTIES.

Authors:  T OMURA; R SATO
Journal:  J Biol Chem       Date:  1964-07       Impact factor: 5.157

3.  Biothermodynamic characterization of erythrocyte hemolysis induced by phenothiazine derivatives and anti-inflammatory drugs.

Authors:  H Aki; M Yamamoto
Journal:  Biochem Pharmacol       Date:  1990-01-15       Impact factor: 5.858

4.  Decreased viscosity of human erythrocyte suspension induced by chlorpromazine and isoxsuprine.

Authors:  T Suda; D Shimizu; N Maeda; T Shiga
Journal:  Biochem Pharmacol       Date:  1981-08-01       Impact factor: 5.858

5.  Cytochrome P-450 cholesterol 7 alpha-hydroxylase: inhibition of enzyme deactivation by structurally diverse calmodulin antagonists and phosphatase inhibitors.

Authors:  E J Holsztynska; D J Waxman
Journal:  Arch Biochem Biophys       Date:  1987-08-01       Impact factor: 4.013

6.  Late preventive effects of trifluoperazine on carbon tetrachloride-induced hepatic necrosis.

Authors:  M C Villarruel; G Fernández; E C de Ferreyra; O M de Fenos; J A Castro
Journal:  Toxicol Appl Pharmacol       Date:  1986-04       Impact factor: 4.219

7.  Red blood cell partitioning, protein binding and lipophilicity of six phenothiazines.

Authors:  P J Marroum; S H Curry
Journal:  J Pharm Pharmacol       Date:  1993-01       Impact factor: 3.765

8.  A kinetic study of the generation and decomposition of some phenothiazine free radicals formed during enzymatic oxidation of phenothiazines by peroxidase-hydrogen peroxide.

Authors:  A Vázquez; J Tudela; R Varón; F García-Cánovas
Journal:  Biochem Pharmacol       Date:  1992-09-01       Impact factor: 5.858

9.  Involvement of erythrocyte skeletal proteins in the modulation of membrane fluidity by phenothiazines.

Authors:  M Minetti; A M Di Stasi
Journal:  Biochemistry       Date:  1987-12-15       Impact factor: 3.162

10.  Phenothiazines inhibit acetylcholinesterase by concentration-dependent-type kinetics. A study with trifluoperazine and perphenazine.

Authors:  A Spinedi; L Pacini; C Limatola; P Luly; R N Farias
Journal:  Biochem Pharmacol       Date:  1992-10-20       Impact factor: 5.858
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