Literature DB >> 1530657

A kinetic study of the generation and decomposition of some phenothiazine free radicals formed during enzymatic oxidation of phenothiazines by peroxidase-hydrogen peroxide.

A Vázquez1, J Tudela, R Varón, F García-Cánovas.   

Abstract

A kinetic study of the oxidation of four different phenothiazines (Pts) by peroxidase-hydrogen peroxide was carried out. The free radical formed during the enzymatic oxidation suffers a non-enzymatic breakdown and the overall system was analysed and characterized. The non-enzymatic breakdown of the cation radical does not occur through a disproportionation mechanism but through a more complex mechanism. The kinetic parameters of the overall system were determined for the different Pts. These experimental data may serve in the understanding of the pharmacological action of Pts.

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Year:  1992        PMID： 1530657     DOI： 10.1016/0006-2952(92)90120-8

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN： 0006-2952            Impact factor:   5.858


  5 in total

1.  Kinetics of an enzyme reaction in which both the enzyme-substrate complex and the product are unstable or only the product is unstable.

Authors:  C Garrido-del Solo; F García-Cánovas; B H Havsteen; E Valero; R Varón
Journal:  Biochem J       Date:  1994-10-15       Impact factor: 3.857

2.  Susceptibility of melanized and nonmelanized Cryptococcus neoformans to the melanin-binding compounds trifluoperazine and chloroquine.

Authors:  Y Wang; A Casadevall
Journal:  Antimicrob Agents Chemother       Date:  1996-03       Impact factor: 5.191

3.  Chlorpromazine inhibits nitric oxide-mediated increase in intracellular cGMP in a mouse teratocarcinoma cell line.

Authors:  M Fratelli; R Delgado; M Zinetti; G Galli; Y Rolland; P Ghezzi
Journal:  Inflamm Res       Date:  1995-07       Impact factor: 4.575

4.  Chlorpromazine inhibits tumour necrosis factor synthesis and cytotoxicity in vitro.

Authors:  M Zinetti; G Galli; M T Demitri; G Fantuzzi; M Minto; P Ghezzi; R Alzani; E Cozzi; M Fratelli
Journal:  Immunology       Date:  1995-11       Impact factor: 7.397

5.  Mouse liver microsomes (MLM) protect erythrocytes against trifluoperazine (TFP) induced and mechanical hemolysis which are due to TFP microsomal transformation and to the action of an unidentified water-soluble microsomal factor (UF).

Authors:  N C Meirelles; S V Malheiros; A C Ruggiero; I A Degterev
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1994 Oct-Dec       Impact factor: 2.441
  5 in total

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