Literature DB >> 7734306

The association of preoperative serum tumour markers with Dukes' stage and survival in colorectal cancer.

G Lindmark1, R Bergström, L Påhlman, B Glimelius.   

Abstract

The tumour markers carcinoembryonic antigen (CEA), tissue polypeptide antigen (TPA), TPS, CA 19-9, CA 50 and CA 242 were analysed in serum from 203 potentially curable colorectal cancer patients. The levels of all markers increased with increasing tumour stage, and all markers correlated with survival. Multivariate analyses indicated that the Dukes stage had the best prognostic explanatory power, followed by TPA. In the subset of 166 potentially cured patients, the prognostic information by the markers was substantially reduced. We conclude that preoperative serum tumour marker measurements have the potential to aid therapy selection, but also that their clinical usefulness is not immediately apparent.

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Year:  1995        PMID： 7734306      PMCID： PMC2033799          DOI： 10.1038/bjc.1995.211

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  22 in total

1.  The role of tumour markers (CEA, TPA, CA 19-9) in colon and rectum carcinomas.

Authors:  V Cangemi; P Volpino; E Fiori; A Giammarco; G Piat
Journal:  J Nucl Med Allied Sci       Date:  1987 Apr-Jun

2.  Measurement of a monoclonal-antibody-defined antigen (CA19-9) in the sera of patients with malignant and nonmalignant diseases. Comparison with carcinoembryonic antigen.

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Journal:  Cancer       Date:  1985-07-15       Impact factor: 6.860

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Authors:  H Koprowski; Z Steplewski; K Mitchell; M Herlyn; D Herlyn; P Fuhrer
Journal:  Somatic Cell Genet       Date:  1979-11

4.  Detection by monoclonal antibody of carbohydrate antigen CA 50 in serum of patients with carcinoma.

Authors:  J Holmgren; L Lindholm; B Persson; T Lagergård; O Nilsson; L Svennerholm; C M Rudenstam; B Unsgaard; F Yngvason; S Pettersson
Journal:  Br Med J (Clin Res Ed)       Date:  1984-05-19

5.  The preoperative carcinoembryonic antigen test in the diagnosis, staging, and prognosis of colorectal cancer.

Authors:  C G Moertel; J R O'Fallon; V L Go; M J O'Connell; G S Thynne
Journal:  Cancer       Date:  1986-08-01       Impact factor: 6.860

6.  Pre-operative carcino-embryonic antigen and survival in patients with colorectal cancer.

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Journal:  Br J Surg       Date:  1984-03       Impact factor: 6.939

7.  Comparison of the tumor markers CEA, TPA, and CA 19-9 in colorectal carcinoma.

Authors:  H Putzki; A Student; M Jablonski; H Heymann
Journal:  Cancer       Date:  1987-01-15       Impact factor: 6.860

8.  A randomized controlled trial of adjuvant portal vein cytotoxic perfusion in colorectal cancer.

Authors:  I Taylor; D Machin; M Mullee; G Trotter; T Cooke; C West
Journal:  Br J Surg       Date:  1985-05       Impact factor: 6.939

9.  The grading of rectal cancer: historical perspectives and a multivariate analysis of 447 cases.

Authors:  J R Jass; W S Atkin; J Cuzick; H J Bussey; B C Morson; J M Northover; I P Todd
Journal:  Histopathology       Date:  1986-05       Impact factor: 5.087

10.  The spread of rectal cancer and its effect on prognosis.

Authors:  C E DUKES; H J BUSSEY
Journal:  Br J Cancer       Date:  1958-09       Impact factor: 7.640
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  12 in total

1.  Investigation of nonspecific cross-reacting antigen 2 as a prognostic biomarker in bone marrow plasma from colorectal cancer patients.

Authors:  Kristina Schee; Kjersti Flatmark; Ruth Holm; Kjetil Boye; Elisabeth Paus
Journal:  Tumour Biol       Date:  2011-10-18

2.  Incorporation of serum carcinoembryonic antigen levels into the prognostic grouping system of colon cancer.

Authors:  Heita Ozawa; Kenjiro Kotake; Miki Hosaka; Akira Hirata; Yusuke Nakagawa; Shin Fujita; Kenichi Sugihara
Journal:  Int J Colorectal Dis       Date:  2017-02-09       Impact factor: 2.571

3.  Differences in plasma gastrin, CEA, and CA 19-9 concentration in patients with proximal and distal colorectal cancer.

Authors:  Grzegorz Bombski; Anita Gasiorowska; Daria Orszulak-Michalak; Beata Neneman; Justyna Kotynia; Janusz Strzelczyk; Adam Janiak; Ewa Malecka-Panas
Journal:  Int J Gastrointest Cancer       Date:  2002

4.  Cytokeratins and carcinoembryonic antigen in diagnosis, staging and prognosis of colorectal adenocarcinoma.

Authors:  Luís C Fernandes; Su B Kim; Delcio Matos
Journal:  World J Gastroenterol       Date:  2005-02-07       Impact factor: 5.742

5.  Clinical presentation predicts the outcome of patients with colon cancer.

Authors:  Offir Ben-Ishay; Zvi Peled; Amira Othman; Eran Brauner; Yoram Kluger
Journal:  World J Gastrointest Surg       Date:  2013-04-27

6.  Prognostic implications of BAX protein expression and microsatellite instability in all non-metastatic stages of primary colon cancer treated by surgery alone.

Authors:  Oliver Nehls; Holger G Hass; Thomas Okech; Silke Zenner; Chih-Jen Hsieh; Mario Sarbia; Franz Borchard; Hans-Helmut Gruenagel; Vera Gaco; Rainer Porschen; Michael Gregor; Bodo Klump
Journal:  Int J Colorectal Dis       Date:  2009-02-17       Impact factor: 2.571

7.  Stromal tenascin distribution as a prognostic marker in colorectal cancer.

Authors:  U Kressner; G Lindmark; B Tomasini-Johansson; R Bergström; B Gerdin; L Påhlman; B Glimelius
Journal:  Br J Cancer       Date:  1997       Impact factor: 7.640

8.  Comparison of carcinoembryonic antigen prognostic value in serum and tumour tissue of patients with colorectal cancer.

Authors:  M Li; J-Y Li; A-L Zhao; J-S He; L-X Zhou; Y-A Li; J Gu
Journal:  Colorectal Dis       Date:  2008-05-29       Impact factor: 3.788

9.  Increased serum p53 antibody levels indicate poor prognosis in patients with colorectal cancer.

Authors:  U Kressner; B Glimelius; R Bergström; L Påhlman; A Larsson; G Lindmark
Journal:  Br J Cancer       Date:  1998-06       Impact factor: 7.640

10.  Preoperative carcinoembryonic antigen is related to tumour stage and long-term survival in colorectal cancer.

Authors:  M A Chapman; D Buckley; D B Henson; N C Armitage
Journal:  Br J Cancer       Date:  1998-11       Impact factor: 7.640
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