PURPOSE: This study examined whether the apoptosis-related protein, BAX, or the microsatellite-instability phenotype provide prognostic information in patients with resected colon cancer. METHODS: A total of 371 stage I-III patients that previously underwent radical surgery were included (mean follow-up 51.8 months). BAX expression was examined by immunohistochemical staining; high-frequency microsatellite instability (MSI+) was determined by assessing the specific marker, BAT26, using single-strand conformation polymorphism (SSCP)-based analysis. RESULTS: High BAX expression was found in 66.4% of patients. MSI+ tumors were observed in 14.8% of 344 patients. Univariate analysis showed that unlike MSI, low BAX expression was significantly correlated with poor disease-specific overall survival (OS) in stages I-III (p = 0.04). Multivariate subgroup analyses revealed that unlike MSI, low BAX was an independent predictor for OS in stage II (p = 0.009); however, in stages I or III, BAX or MSI were not independent predictors of OS. CONCLUSIONS: In stage II colon cancer treated with surgery alone, BAX protein expression may be a predictor for prognosis.
PURPOSE: This study examined whether the apoptosis-related protein, BAX, or the microsatellite-instability phenotype provide prognostic information in patients with resected colon cancer. METHODS: A total of 371 stage I-III patients that previously underwent radical surgery were included (mean follow-up 51.8 months). BAX expression was examined by immunohistochemical staining; high-frequency microsatellite instability (MSI+) was determined by assessing the specific marker, BAT26, using single-strand conformation polymorphism (SSCP)-based analysis. RESULTS: High BAX expression was found in 66.4% of patients. MSI+ tumors were observed in 14.8% of 344 patients. Univariate analysis showed that unlike MSI, low BAX expression was significantly correlated with poor disease-specific overall survival (OS) in stages I-III (p = 0.04). Multivariate subgroup analyses revealed that unlike MSI, low BAX was an independent predictor for OS in stage II (p = 0.009); however, in stages I or III, BAX or MSI were not independent predictors of OS. CONCLUSIONS: In stage II colon cancer treated with surgery alone, BAX protein expression may be a predictor for prognosis.
Authors: Katharina Schelwies; Isrid Sturm; Patricia Grabowski; Hans Scherübl; Isabell Schindler; Sandra Hermann; Harald Stein; Heinz-Johannes Buhr; Ernst O Riecken; Martin Zeitz; Bernd Dörken; Peter T Daniel Journal: Int J Cancer Date: 2002-06-01 Impact factor: 7.396
Authors: Oliver Nehls; Thomas Okech; Chih-Jen Hsieh; Mario Sarbia; Franz Borchard; Hans-Helmut Gruenagel; Vera Gaco; Rainer Porschen; Michael Gregor; Bodo Klump Journal: Int J Radiat Oncol Biol Phys Date: 2005-01-01 Impact factor: 7.038
Authors: Cathy Wang; Marius van Rijnsoever; Fabienne Grieu; Sean Bydder; Hsny Elsaleh; David Joseph; Jennet Harvey; Barry Iacopetta Journal: Oncology Date: 2003 Impact factor: 2.935
Authors: Venkat R Katkoori; Catalina Suarez-Cuervo; Chandrakumar Shanmugam; Nirag C Jhala; Tom Callens; Ludwine Messiaen; James Posey; Harvey L Bumpers; Sreelatha Meleth; William E Grizzle; Upender Manne Journal: J Gastrointest Oncol Date: 2010-12