Literature DB >> 7732032

Maintenance of protective immunity against malaria by persistent hepatic parasites derived from irradiated sporozoites.

L F Scheller1, A F Azad.   

Abstract

Immunization of rodents and humans with irradiation-attenuated malaria sporozoites confers preerythrocytic stage-specific protective immunity to challenge infection. This immunity is directed against intrahepatic parasites and involves T cells and interferon gamma, which prevent development of exoerythrocytic stages and subsequent blood infection. The present study was undertaken to determine how protective immunity is achieved after immunization of rodent hosts with irradiated Plasmodium berghei sporozoites. We present evidence that irradiated parasites persist in hepatocytes of rats and mice for up to 6 months after immunization. A relationship between the persistence of parasites and the maintenance of protective immunity was observed. Protective immunity was abrogated in irradiated-sporozoite-immunized rats following the application of chemotherapy to remove preexisting liver parasites. Additionally, protective immunity against sporozoite challenge was established in rats vaccinated with early and late hepatic stages of irradiated parasites. These results show that irradiation-attenuated sporozoites produce persistent intrahepatic stages in vivo necessary for the induction and maintenance of protective immunity.

Entities:  

Mesh：

Substances：

Year:  1995        PMID： 7732032      PMCID： PMC42103          DOI： 10.1073/pnas.92.9.4066

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  15 in total

1.  Generation of chromosome size polymorphism during in vivo mitotic multiplication of Plasmodium berghei involves both loss and addition of subtelomeric repeat sequences.

Authors:  M Ponzi; C J Janse; E Dore; R Scotti; T Pace; T J Reterink; F M van der Berg; B Mons
Journal:  Mol Biochem Parasitol       Date:  1990-06       Impact factor: 1.759

2.  Survival and antigenic profile of irradiated malarial sporozoites in infected liver cells.

Authors:  A Suhrbier; L A Winger; E Castellano; R E Sinden
Journal:  Infect Immun       Date:  1990-09       Impact factor: 3.441

3.  Detection of different developmental stages of malaria parasites by non-radioactive DNA in situ hybridization.

Authors:  F M Van den Berg; P J Van Amstel; C J Janse; J F Meis; B Mons
Journal:  Histochem J       Date:  1991-03

4.  Transformation of sporozoites of Plasmodium berghei into exoerythrocytic forms in the liver of its mammalian host.

Authors:  J F Meis; J P Verhave; P H Jap; J H Meuwissen
Journal:  Cell Tissue Res       Date:  1985       Impact factor: 5.249

5.  In vitro infectivity of irradiated Plasmodium berghei sporozoites to cultured hepatoma cells.

Authors:  C I Sigler; P Leland; M R Hollingdale
Journal:  Am J Trop Med Hyg       Date:  1984-07       Impact factor: 2.345

6.  Comparative studies on the immunogenicity of infective and attenuated sporozoites of Plasmodium berghei.

Authors:  A U Orjih; A H Cochrane; R S Nussenzweig
Journal:  Trans R Soc Trop Med Hyg       Date:  1982       Impact factor: 2.184

7.  Protective immunity produced by the injection of x-irradiated sporozoites of Plasmodium berghei. IV. Dose response, specificity and humoral immunity.

Authors:  R Nussenzweig; J Vanderberg; H Most
Journal:  Mil Med       Date:  1969-09       Impact factor: 1.437

8.  Rapid, large-scale isolation of Plasmodium berghei sporozoites from infected mosquitoes.

Authors:  N D Pacheco; C P Strome; F Mitchell; M P Bawden; R L Beaudoin
Journal:  J Parasitol       Date:  1979-06       Impact factor: 1.276

9.  Plasmodium berghei: production and quantitation of hepatic stages derived from irradiated sporozoites in rats and mice.

Authors:  L F Scheller; K C Stump; A F Azad
Journal:  J Parasitol       Date:  1995-02       Impact factor: 1.276

10.  Efficacy of murine malaria sporozoite vaccines: implications for human vaccine development.

Authors:  J E Egan; J L Weber; W R Ballou; M R Hollingdale; W R Majarian; D M Gordon; W L Maloy; S L Hoffman; R A Wirtz; I Schneider
Journal:  Science       Date:  1987-04-24       Impact factor: 47.728
View more
  37 in total

1.  Immunization with genetically attenuated P52-deficient Plasmodium berghei sporozoites induces a long-lasting effector memory CD8+ T cell response in the liver.

Authors:  Bruno Douradinha; Melissa van Dijk; Geert-Jan van Gemert; Shahid M Khan; Chris J Janse; Andy P Waters; Robert W Sauerwein; Adrian Jf Luty; Bruno Silva-Santos; Maria M Mota; Sabrina Epiphanio
Journal:  J Immune Based Ther Vaccines       Date:  2011-10-17

2.  Immunity and protection, the unfolding of a tale.

Authors:  Maurizio Zanetti
Journal:  Immunol Res       Date:  2007       Impact factor: 2.829

Review 3.  Platform for Plasmodium vivax vaccine discovery and development.

Authors:  Sócrates Herrera Valencia; Diana Carolina Rodríguez; Diana Lucía Acero; Vanessa Ocampo; Myriam Arévalo-Herrera
Journal:  Mem Inst Oswaldo Cruz       Date:  2011-08       Impact factor: 2.743

4.  Immunogenicity of four Plasmodium falciparum preerythrocytic antigens in Aotus lemurinus monkeys.

Authors:  B L Perlaza; M Arévalo-Herrera; K Brahimi; G Quintero; J C Palomino; H Gras-Masse; A Tartar; P Druilhe; S Herrera
Journal:  Infect Immun       Date:  1998-07       Impact factor: 3.441

5.  Genetically attenuated, P36p-deficient malarial sporozoites induce protective immunity and apoptosis of infected liver cells.

Authors:  Melissa R van Dijk; Bruno Douradinha; Blandine Franke-Fayard; Volker Heussler; Maaike W van Dooren; Ben van Schaijk; Geert-Jan van Gemert; Robert W Sauerwein; Maria M Mota; Andrew P Waters; Chris J Janse
Journal:  Proc Natl Acad Sci U S A       Date:  2005-08-15       Impact factor: 11.205

6.  The survival of memory CD8 T cells that is mediated by IL-15 correlates with sustained protection against malaria.

Authors:  Stasya Zarling; Dmitriy Berenzon; Sarat Dalai; Dmitry Liepinsh; Nick Steers; Urszula Krzych
Journal:  J Immunol       Date:  2013-04-15       Impact factor: 5.422

Review 7.  Genetically engineered, attenuated whole-cell vaccine approaches for malaria.

Authors:  Ashley M Vaughan; Ruobing Wang; Stefan H I Kappe
Journal:  Hum Vaccin       Date:  2010-01-29

8.  Why functional pre-erythrocytic and bloodstage malaria vaccines fail: a meta-analysis of fully protective immunizations and novel immunological model.

Authors:  D Lys Guilbride; Pawel Gawlinski; Patrick D L Guilbride
Journal:  PLoS One       Date:  2010-05-19       Impact factor: 3.240

9.  Prolonged antigen presentation is required for optimal CD8+ T cell responses against malaria liver stage parasites.

Authors:  Ian A Cockburn; Yun-Chi Chen; Michael G Overstreet; Jason R Lees; Nico van Rooijen; Donna L Farber; Fidel Zavala
Journal:  PLoS Pathog       Date:  2010-05-06       Impact factor: 6.823

10.  Extreme CD8 T cell requirements for anti-malarial liver-stage immunity following immunization with radiation attenuated sporozoites.

Authors:  Nathan W Schmidt; Noah S Butler; Vladimir P Badovinac; John T Harty
Journal:  PLoS Pathog       Date:  2010-07-15       Impact factor: 6.823
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.