Literature DB >> 6089599

In vitro infectivity of irradiated Plasmodium berghei sporozoites to cultured hepatoma cells.

C I Sigler, P Leland, M R Hollingdale.   

Abstract

The invasion of gamma-irradiated Plasmodium berghei sporozoites into cultured hepatoma cells and their transformation into trophozoites was similar to invasion and transformation of non-irradiated sporozoites. However, trophozoites from irradiated sporozoites did not further develop into schizonts, but persisted within the cells for up to 3 days. Sporozoite surface protective antigen was present in trophozoites from irradiated and non-irradiated sporozoites, suggesting that hepatocyte antigen processing may contribute to the induction of anti-malarial immunity.

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Year:  1984        PMID： 6089599     DOI： 10.4269/ajtmh.1984.33.544

Source DB:  PubMed          Journal:  Am J Trop Med Hyg        ISSN： 0002-9637            Impact factor:   2.345


  15 in total

1.  Survival and antigenic profile of irradiated malarial sporozoites in infected liver cells.

Authors:  A Suhrbier; L A Winger; E Castellano; R E Sinden
Journal:  Infect Immun       Date:  1990-09       Impact factor: 3.441

2.  Detection of different developmental stages of malaria parasites by non-radioactive DNA in situ hybridization.

Authors:  F M Van den Berg; P J Van Amstel; C J Janse; J F Meis; B Mons
Journal:  Histochem J       Date:  1991-03

Review 3.  Developmental biology of sporozoite-host interactions in Plasmodium falciparum malaria: implications for vaccine design.

Authors:  Javier E Garcia; Alvaro Puentes; Manuel E Patarroyo
Journal:  Clin Microbiol Rev       Date:  2006-10       Impact factor: 26.132

4.  Early transcriptional responses of HepG2-A16 liver cells to infection by Plasmodium falciparum sporozoites.

Authors:  Rana Chattopadhyay; Patricia de la Vega; Sun H Paik; Yoko Murata; Earl W Ferguson; Thomas L Richie; Guck T Ooi
Journal:  J Biol Chem       Date:  2011-06-07       Impact factor: 5.157

5.  Why functional pre-erythrocytic and bloodstage malaria vaccines fail: a meta-analysis of fully protective immunizations and novel immunological model.

Authors:  D Lys Guilbride; Pawel Gawlinski; Patrick D L Guilbride
Journal:  PLoS One       Date:  2010-05-19       Impact factor: 3.240

6.  Chemical attenuation of Plasmodium berghei sporozoites induces sterile immunity in mice.

Authors:  Lisa A Purcell; Stephanie K Yanow; Moses Lee; Terry W Spithill; Ana Rodriguez
Journal:  Infect Immun       Date:  2008-01-03       Impact factor: 3.441

Review 7.  Acquired immunity to malaria.

Authors:  Denise L Doolan; Carlota Dobaño; J Kevin Baird
Journal:  Clin Microbiol Rev       Date:  2009-01       Impact factor: 26.132

8.  Maintenance of protective immunity against malaria by persistent hepatic parasites derived from irradiated sporozoites.

Authors:  L F Scheller; A F Azad
Journal:  Proc Natl Acad Sci U S A       Date:  1995-04-25       Impact factor: 11.205

Review 9.  Immunity to liver stage malaria: considerations for vaccine design.

Authors:  Andrew W Taylor-Robinson
Journal:  Immunol Res       Date:  2003       Impact factor: 2.829

10.  Characterization of immunoglobulin G antibodies to Plasmodium falciparum sporozoite surface antigen MB2 in malaria exposed individuals.

Authors:  Thanh V Nguyen; John B Sacci; Patricia de la Vega; Chandy C John; Anthony A James; Angray S Kang
Journal:  Malar J       Date:  2009-10-23       Impact factor: 2.979
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