Literature DB >> 7731996

Degradation of the cleaved leader peptide of thiolase by a peroxisomal proteinase.

F Authier1, J J Bergeron, W J Ou, R A Rachubinski, B I Posner, P A Walton.   

Abstract

A peroxisomal location for insulin-degrading enzyme (IDE) has been defined by confocal immunofluorescence microscopy of stably transfected CHO cells overexpressing IDE and digitonin-permeabilization studies in normal nontransfected fibroblasts. The functional significance of IDE in degrading cleaved leader peptides of peroxisomal proteins targeted by the type II motif was evaluated with a synthetic peptide corresponding to the type II leader peptide of prethiolase. The peptide effectively competed for degradation and cross-linking of the high-affinity substrate 125I-labeled insulin to IDE. Direct proteolysis of the leader peptide of prethiolase was confirmed by HPLC; degradation was inhibited by immunodepletion with an antibody to IDE. Phylogenetic analysis of proteinases related to IDE revealed sequence similarity to mitochondrial processing peptidases.

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Year:  1995        PMID： 7731996      PMCID： PMC42061          DOI： 10.1073/pnas.92.9.3859

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  24 in total

Review 1.  Biochemistry of peroxisomes.

Authors:  H van den Bosch; R B Schutgens; R J Wanders; J M Tager
Journal:  Annu Rev Biochem       Date:  1992       Impact factor: 23.643

Review 2.  Protein import into peroxisomes and biogenesis of the organelle.

Authors:  S Subramani
Journal:  Annu Rev Cell Biol       Date:  1993

3.  Endosomal proteolysis of insulin by an acidic thiol metalloprotease unrelated to insulin degrading enzyme.

Authors:  F Authier; R A Rachubinski; B I Posner; J J Bergeron
Journal:  J Biol Chem       Date:  1994-01-28       Impact factor: 5.157

4.  The sequence of the gene encoding elongation factor Tu from Chlamydia trachomatis compared with those of other organisms.

Authors:  B Cousineau; C Cerpa; J Lefebvre; R Cedergren
Journal:  Gene       Date:  1992-10-12       Impact factor: 3.688

5.  Transport of microinjected proteins into peroxisomes of mammalian cells: inability of Zellweger cell lines to import proteins with the SKL tripeptide peroxisomal targeting signal.

Authors:  P A Walton; S J Gould; J R Feramisco; S Subramani
Journal:  Mol Cell Biol       Date:  1992-02       Impact factor: 4.272

6.  The rat insulin-degrading enzyme. Molecular cloning and characterization of tissue-specific transcripts.

Authors:  H Baumeister; D Müller; M Rehbein; D Richter
Journal:  FEBS Lett       Date:  1993-02-15       Impact factor: 4.124

7.  Inducible expression and cellular localization of insulin-degrading enzyme in a stably transfected cell line.

Authors:  W L Kuo; B D Gehm; M R Rosner; W Li; G Keller
Journal:  J Biol Chem       Date:  1994-09-09       Impact factor: 5.157

8.  Membrane assembly from purified components. I. Isolated M13 procoat does not require ribosomes or soluble proteins for processing by membranes.

Authors:  P Silver; C Watts; W Wickner
Journal:  Cell       Date:  1981-08       Impact factor: 41.582

Review 9.  The non-specific lipid-transfer protein (sterol carrier protein 2) and its relationship to peroxisomes.

Authors:  B C Ossendorp; K W Wirtz
Journal:  Biochimie       Date:  1993       Impact factor: 4.079

10.  A novel, cleavable peroxisomal targeting signal at the amino-terminus of the rat 3-ketoacyl-CoA thiolase.

Authors:  B W Swinkels; S J Gould; A G Bodnar; R A Rachubinski; S Subramani
Journal:  EMBO J       Date:  1991-11       Impact factor: 11.598
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  25 in total

1.  Two proteases, trypsin domain-containing 1 (Tysnd1) and peroxisomal lon protease (PsLon), cooperatively regulate fatty acid β-oxidation in peroxisomal matrix.

Authors:  Kanji Okumoto; Yukari Kametani; Yukio Fujiki
Journal:  J Biol Chem       Date:  2011-10-14       Impact factor: 5.157

2.  A common genetic system for functional studies of pitrilysin and related M16A proteases.

Authors:  Benjamin J Alper; Tatyana E Nienow; Walter K Schmidt
Journal:  Biochem J       Date:  2006-08-15       Impact factor: 3.857

Review 3.  The surprising complexity of peroxisome biogenesis.

Authors:  L J Olsen
Journal:  Plant Mol Biol       Date:  1998-09       Impact factor: 4.076

4.  Characterization of endoproteases from plant peroxisomes.

Authors:  S Distefano; J M Palma; M Gómez; L A Río
Journal:  Biochem J       Date:  1997-10-15       Impact factor: 3.857

5.  Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme.

Authors:  K Vekrellis; Z Ye; W Q Qiu; D Walsh; D Hartley; V Chesneau; M R Rosner; D J Selkoe
Journal:  J Neurosci       Date:  2000-03-01       Impact factor: 6.167

6.  Uptake and metabolic fate of [HisA8,HisB4,GluB10,HisB27]insulin in rat liver in vivo.

Authors:  F Authier; G M Di Guglielmo; G M Danielsen; J J Bergeron
Journal:  Biochem J       Date:  1998-06-01       Impact factor: 3.857

Review 7.  Insulin receptor internalization and signalling.

Authors:  G M Di Guglielmo; P G Drake; P C Baass; F Authier; B I Posner; J J Bergeron
Journal:  Mol Cell Biochem       Date:  1998-05       Impact factor: 3.396

8.  Association of insulin-degrading enzyme with a 70 kDa cytosolic protein in hepatoma cells.

Authors:  F Authier; P H Cameron; V Taupin
Journal:  Biochem J       Date:  1996-10-01       Impact factor: 3.857

9.  Expression of metalloprotease insulin-degrading enzyme insulysin in normal and malignant human tissues.

Authors:  Christina Yfanti; Karin Mengele; Apostolos Gkazepis; Gregor Weirich; Cecylia Giersig; Wen-Liang Kuo; Wei-Jen Tang; Marsha Rosner; Manfred Schmitt
Journal:  Int J Mol Med       Date:  2008-10       Impact factor: 4.101

10.  Immunohistochemical evidence of ubiquitous distribution of the metalloendoprotease insulin-degrading enzyme (IDE; insulysin) in human non-malignant tissues and tumor cell lines.

Authors:  Gregor Weirich; Karin Mengele; Christina Yfanti; Apostolos Gkazepis; Daniela Hellmann; Anita Welk; Cecylia Giersig; Wen-Liang Kuo; Marsha Rich Rosner; Wei-Jen Tang; Manfred Schmitt
Journal:  Biol Chem       Date:  2008-11       Impact factor: 3.915
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