Literature DB >> 8425612

The rat insulin-degrading enzyme. Molecular cloning and characterization of tissue-specific transcripts.

H Baumeister1, D Müller, M Rehbein, D Richter.   

Abstract

The primary structure of the rat insulin-degrading enzyme (IDE) was determined by cDNA analysis. Rat IDE, as well as the previously characterized homologs from human and Drosophila, contain the carboxyl-terminal consensus sequence A/S-K-L, for peroxisome targeting. A stretch of 43 bp surrounding an alternatively used polyadenylation site is highly conserved between rat and human, suggesting that it may contain important regulatory information. Northern blot analysis revealed two IDE transcripts of 3.7 and 5.5 kb in various tissues. Testis was found to be exceptional in having three different RNAs (3.7, 4.1 and 6.1 kb) at a relatively high abundance. The expression of the IDE gene in testis is correlated with sexual maturation.

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Year:  1993        PMID： 8425612     DOI： 10.1016/0014-5793(93)81286-9

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  19 in total

1.  Purified recombinant insulin-degrading enzyme degrades amyloid beta-protein but does not promote its oligomerization.

Authors:  V Chesneau; K Vekrellis; M R Rosner; D J Selkoe
Journal:  Biochem J       Date:  2000-10-15       Impact factor: 3.857

2.  N-arginine dibasic convertase (nardilysin) isoforms are soluble dibasic-specific metalloendopeptidases that localize in the cytoplasm and at the cell surface.

Authors:  V Hospital; V Chesneau; A Balogh; C Joulie; N G Seidah; P Cohen; A Prat
Journal:  Biochem J       Date:  2000-07-15       Impact factor: 3.857

3.  Human and rat testis express two mRNA species encoding variants of NRD convertase, a metalloendopeptidase of the insulinase family.

Authors:  V Hospital; A Prat; C Joulie; D Chérif; R Day; P Cohen
Journal:  Biochem J       Date:  1997-11-01       Impact factor: 3.857

4.  Yeast Ste23p shares functional similarities with mammalian insulin-degrading enzymes.

Authors:  Benjamin J Alper; Jarrad W Rowse; Walter K Schmidt
Journal:  Yeast       Date:  2009-11       Impact factor: 3.239

5.  Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme.

Authors:  K Vekrellis; Z Ye; W Q Qiu; D Walsh; D Hartley; V Chesneau; M R Rosner; D J Selkoe
Journal:  J Neurosci       Date:  2000-03-01       Impact factor: 6.167

6.  N-arginine dibasic convertase, a metalloendopeptidase as a prototype of a class of processing enzymes.

Authors:  A R Pierotti; A Prat; V Chesneau; F Gaudoux; A M Leseney; T Foulon; P Cohen
Journal:  Proc Natl Acad Sci U S A       Date:  1994-06-21       Impact factor: 11.205

7.  Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo.

Authors:  Bonnie C Miller; Elizabeth A Eckman; Kumar Sambamurti; Nicole Dobbs; K Martin Chow; Christopher B Eckman; Louis B Hersh; Dwain L Thiele
Journal:  Proc Natl Acad Sci U S A       Date:  2003-05-05       Impact factor: 11.205

8.  In vitro degradation of insulin-like peptide 3 by insulin-degrading enzyme.

Authors:  Wei-Jie Zhang; Xiao Luo; Zhan-Yun Guo
Journal:  Protein J       Date:  2010-02       Impact factor: 2.371

9.  The metalloendopeptidase nardilysin (NRDc) is potently inhibited by heparin-binding epidermal growth factor-like growth factor (HB-EGF).

Authors:  Véronique Hospital; Eiichiro Nishi; Michael Klagsbrun; Paul Cohen; Nabil G Seidah; Annik Prat
Journal:  Biochem J       Date:  2002-10-01       Impact factor: 3.857

Review 10.  The degradation of amyloid beta as a therapeutic strategy in Alzheimer's disease and cerebrovascular amyloidoses.

Authors:  Laura Morelli; Ramiro Llovera; Sandra Ibendahl; Eduardo M Castaño
Journal:  Neurochem Res       Date:  2002-11       Impact factor: 3.996
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