Literature DB >> 7731681

The expression of the high mobility group HMGI (Y) proteins correlates with the malignant phenotype of human thyroid neoplasias.

G Chiappetta1, A Bandiera, M T Berlingieri, R Visconti, G Manfioletti, S Battista, F J Martinez-Tello, M Santoro, V Giancotti, A Fusco.   

Abstract

High Mobility Group I (HMGI) proteins are nuclear proteins involved in the regulation of chromatin structure and function. Elevated expression of the HMGI proteins (HMGI, HMGY and HMGI-C) has been correlated with the presence of a highly malignant phenotype in epithelial and fibroblastic rat thyroid cells, and in several experimental carcinomas. Here, we demonstrate that HMGI and HMGY proteins are expressed in human thyroid carcinomas and thyroid carcinoma cell lines, but not in adenomas, goiters, normal thyroid tissues and cells. These results indicate a correlation between HMGI and HMGY expression and the malignant phenotype of thyroid neoplasias, suggesting that these proteins may be used as markers in thyroid cancer.

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Year:  1995        PMID： 7731681

Source DB:  PubMed          Journal:  Oncogene        ISSN： 0950-9232            Impact factor:   9.867


  52 in total

1.  Expression of the high-mobility group protein HMGI(Y) in human trophoblast: potential role in trophoblast invasion of maternal tissue.

Authors:  Ana-Maria Bamberger; Antonis Makrigiannakis; Kerstin Röser; Jessica Radde; Tanja Carstens; Aljoscha M Flohr; Christoph M Bamberger; Jörn Bullerdiek; Thomas Löning
Journal:  Virchows Arch       Date:  2003-09-11       Impact factor: 4.064

Review 2.  The high mobility group A1 molecular switch: turning on cancer - can we turn it off?

Authors:  Tait H Huso; Linda M S Resar
Journal:  Expert Opin Ther Targets       Date:  2014-03-31       Impact factor: 6.902

3.  Neoplastic transformation of rat thyroid cells requires the junB and fra-1 gene induction which is dependent on the HMGI-C gene product.

Authors:  D Vallone; S Battista; G M Pierantoni; M Fedele; L Casalino; M Santoro; G Viglietto; A Fusco; P Verde
Journal:  EMBO J       Date:  1997-09-01       Impact factor: 11.598

4.  High-mobility-group A1 (HMGA1) proteins down-regulate the expression of the recombination activating gene 2 (RAG2).

Authors:  Sabrina Battista; Monica Fedele; Josefina Martinez Hoyos; Francesca Pentimalli; Giovanna Maria Pierantoni; Rosa Visone; Ivana De Martino; Carlo Maria Croce; Alfredo Fusco
Journal:  Biochem J       Date:  2005-07-01       Impact factor: 3.857

Review 5.  High mobility group A: a novel biomarker and therapeutic target in pancreatic adenocarcinoma.

Authors:  S S Liau; E Whang
Journal:  Surgeon       Date:  2009-10       Impact factor: 2.392

6.  NF-kappaB mediated transcriptional activation is enhanced by the architectural factor HMGI-C.

Authors:  F Mantovani; S Covaceuszach; A Rustighi; R Sgarra; C Heath; G H Goodwin; G Manfioletti
Journal:  Nucleic Acids Res       Date:  1998-03-15       Impact factor: 16.971

7.  Negative regulation of BRCA1 gene expression by HMGA1 proteins accounts for the reduced BRCA1 protein levels in sporadic breast carcinoma.

Authors:  Gustavo Baldassarre; Sabrina Battista; Barbara Belletti; Sanjay Thakur; Francesca Pentimalli; Francesco Trapasso; Monica Fedele; Giovanna Pierantoni; Carlo M Croce; Alfredo Fusco
Journal:  Mol Cell Biol       Date:  2003-04       Impact factor: 4.272

8.  7SK small nuclear RNA transcription level down-regulates in human tumors and stem cells.

Authors:  Mozhgan Abasi; Zahra Bazi; Samira Mohammadi-Yeganeh; Masoud Soleimani; Vahid Haghpanah; Nosratollah Zargami; Hossein Ghanbarian
Journal:  Med Oncol       Date:  2016-10-17       Impact factor: 3.064

9.  High-mobility group A1 proteins are overexpressed in human leukaemias.

Authors:  Giovanna Maria Pierantoni; Valter Agosti; Monica Fedele; Heather Bond; Irene Caliendo; Gennaro Chiappetta; Francesco Lo Coco; Fabrizio Pane; Maria Caterina Turco; Giovanni Morrone; Salvatore Venuta; Alfredo Fusco
Journal:  Biochem J       Date:  2003-05-15       Impact factor: 3.857

10.  Human papilloma virus-dependent HMGA1 expression is a relevant step in cervical carcinogenesis.

Authors:  Massimiliano Mellone; Christian Rinaldi; Isabella Massimi; Marialaura Petroni; Veronica Veschi; Claudio Talora; Silvia Truffa; Helena Stabile; Luigi Frati; Isabella Screpanti; Alberto Gulino; Giuseppe Giannini
Journal:  Neoplasia       Date:  2008-08       Impact factor: 5.715
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