Literature DB >> 19848064

High mobility group A: a novel biomarker and therapeutic target in pancreatic adenocarcinoma.

S S Liau1, E Whang.   

Abstract

High mobility group A1 (HMGA1) proteins are architectural transcriptional factors that are over-expressed in a wide range of human malignancies. Recently published evidence suggests HMGA1 is a promising candidate biomarker and therapeutic target in pancreatic cancer. This review summarises data implicating HMGA1 as an important mediator of progression in human cancer and in pancreatic cancer.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19848064      PMCID： PMC3064443          DOI： 10.1016/s1479-666x(09)80008-5

Source DB:  PubMed          Journal:  Surgeon        ISSN： 1479-666X            Impact factor:   2.392


  93 in total

Review 1.  The hallmarks of cancer.

Authors:  D Hanahan; R A Weinberg
Journal:  Cell       Date:  2000-01-07       Impact factor: 41.582

2.  HMG-I(Y) recognizes base-unpairing regions of matrix attachment sequences and its increased expression is directly linked to metastatic breast cancer phenotype.

Authors:  W M Liu; F K Guerra-Vladusic; S Kurakata; R Lupu; T Kohwi-Shigematsu
Journal:  Cancer Res       Date:  1999-11-15       Impact factor: 12.701

3.  Architectural transcription factor HMGI(Y) promotes tumor progression and mesenchymal transition of human epithelial cells.

Authors:  R Reeves; D D Edberg; Y Li
Journal:  Mol Cell Biol       Date:  2001-01       Impact factor: 4.272

4.  HMG-I/Y, a new c-Myc target gene and potential oncogene.

Authors:  L J Wood; M Mukherjee; C E Dolde; Y Xu; J F Maher; T E Bunton; J B Williams; L M Resar
Journal:  Mol Cell Biol       Date:  2000-08       Impact factor: 4.272

5.  The oncogenic properties of the HMG-I gene family.

Authors:  L J Wood; J F Maher; T E Bunton; L M Resar
Journal:  Cancer Res       Date:  2000-08-01       Impact factor: 12.701

6.  Adenovirus-mediated suppression of HMGI(Y) protein synthesis as potential therapy of human malignant neoplasias.

Authors:  S Scala; G Portella; M Fedele; G Chiappetta; A Fusco
Journal:  Proc Natl Acad Sci U S A       Date:  2000-04-11       Impact factor: 11.205

7.  Pancreatic duct cell carcinomas express high levels of high mobility group I(Y) proteins.

Authors:  N Abe; T Watanabe; T Masaki; T Mori; M Sugiyama; H Uchimura; Y Fujioka; G Chiappetta; A Fusco; Y Atomi
Journal:  Cancer Res       Date:  2000-06-15       Impact factor: 12.701

8.  Inhibition of phosphatidylinositide 3-kinase enhances gemcitabine-induced apoptosis in human pancreatic cancer cells.

Authors:  M S Tsao; S Chow; D W Hedley
Journal:  Cancer Res       Date:  2000-10-01       Impact factor: 12.701

9.  HMG-I/Y is a c-Jun/activator protein-1 target gene and is necessary for c-Jun-induced anchorage-independent growth in Rat1a cells.

Authors:  Fumihiro Hommura; Motoo Katabami; Virna D Leaner; Howard Donninger; Takita F Sumter; Linda M S Resar; Michael J Birrer
Journal:  Mol Cancer Res       Date:  2004-05       Impact factor: 5.852

10.  Expression of the HMGI(Y) gene products in human neuroblastic tumours correlates with differentiation status.

Authors:  G Giannini; C J Kim; L Di Marcotullio; G Manfioletti; B Cardinali; F Cerignoli; E Ristori; M Zani; L Frati; I Screpanti; A Guilino
Journal:  Br J Cancer       Date:  2000-12       Impact factor: 7.640
View more
  6 in total

1.  Elevated expression of HMGA1 correlates with the malignant status and prognosis of non-small cell lung cancer.

Authors:  Ze Zhang; Quan Wang; Feng Chen; Jun Liu
Journal:  Tumour Biol       Date:  2014-10-25

2.  Overexpression of HMGA1 correlates with the malignant status and prognosis of breast cancer.

Authors:  Ruixue Huang; Dequn Huang; Weirong Dai; Fei Yang
Journal:  Mol Cell Biochem       Date:  2015-03-13       Impact factor: 3.396

3.  HMGA1 expression levels are elevated in pancreatic intraepithelial neoplasia cells in the Ptf1a-Cre; LSL-KrasG12D transgenic mouse model of pancreatic cancer.

Authors:  Michelle J Veite-Schmahl; William C Joesten; Michael A Kennedy
Journal:  Br J Cancer       Date:  2017-07-11       Impact factor: 7.640

4.  Adenovirus-Mediated Delivery of Decoy Hyper Binding Sites Targeting Oncogenic HMGA1 Reduces Pancreatic and Liver Cancer Cell Viability.

Authors:  Faizule Hassan; Shuisong Ni; Tyler C Arnett; Melanie C McKell; Michael A Kennedy
Journal:  Mol Ther Oncolytics       Date:  2018-01-31       Impact factor: 7.200

5.  Mandatory role of HMGA1 in human airway epithelial normal differentiation and post-injury regeneration.

Authors:  Haijun Zhang; Jing Yang; Matthew S Walters; Michelle R Staudt; Yael Strulovici-Barel; Jacqueline Salit; Jason G Mezey; Philip L Leopold; Ronald G Crystal
Journal:  Oncotarget       Date:  2018-02-16

6.  Robust prediction of gene regulation in colorectal cancer tissues from DNA methylation profiles.

Authors:  Hagen Klett; Yesilda Balavarca; Reka Toth; Biljana Gigic; Nina Habermann; Dominique Scherer; Petra Schrotz-King; Alexis Ulrich; Peter Schirmacher; Esther Herpel; Hermann Brenner; Cornelia M Ulrich; Karin B Michels; Hauke Busch; Melanie Boerries
Journal:  Epigenetics       Date:  2018-05-03       Impact factor: 4.528
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.