PURPOSE: To determine whether gadolinium can improve the sensitivity and specificity of MR imaging for the initial diagnosis of multiple sclerosis. METHODS: Patients (n = 57) with neurologic symptoms suggesting multiple sclerosis were studied prospectively. MR imaging consisted of T2-weighted and gadolinium-enhanced T1-weighted spin-echo images. Lumbar puncture was performed for cerebrospinal fluid analysis in 34 patients. RESULTS: After imaging, 17 patients (35%) had clinically definite multiple sclerosis. Cerebrospinal fluid examination had a sensitivity of 69% and specificity of 38%. Using liberal criteria, the sensitivity of T2-weighted MR imaging was 94% and the specificity 55%; using more strict criteria, the specificity increased to 65% with a sensitivity of 88%. Gadopentetate dimeglumine enhancement increased the specificity further to 80% with a loss of sensitivity (59%). CONCLUSION: Gadolinium enhancement increases the specificity of MR imaging in the early diagnosis of multiple sclerosis.
PURPOSE: To determine whether gadolinium can improve the sensitivity and specificity of MR imaging for the initial diagnosis of multiple sclerosis. METHODS:Patients (n = 57) with neurologic symptoms suggesting multiple sclerosis were studied prospectively. MR imaging consisted of T2-weighted and gadolinium-enhanced T1-weighted spin-echo images. Lumbar puncture was performed for cerebrospinal fluid analysis in 34 patients. RESULTS: After imaging, 17 patients (35%) had clinically definite multiple sclerosis. Cerebrospinal fluid examination had a sensitivity of 69% and specificity of 38%. Using liberal criteria, the sensitivity of T2-weighted MR imaging was 94% and the specificity 55%; using more strict criteria, the specificity increased to 65% with a sensitivity of 88%. Gadopentetate dimeglumine enhancement increased the specificity further to 80% with a loss of sensitivity (59%). CONCLUSION:Gadolinium enhancement increases the specificity of MR imaging in the early diagnosis of multiple sclerosis.
Authors: M Tintoré; A Rovira; M J Martínez; J Rio; P Díaz-Villoslada; L Brieva; C Borrás; E Grivé; J Capellades; X Montalban Journal: AJNR Am J Neuroradiol Date: 2000-04 Impact factor: 3.825
Authors: J H Simon; D Li; A Traboulsee; P K Coyle; D L Arnold; F Barkhof; J A Frank; R Grossman; D W Paty; E W Radue; J S Wolinsky Journal: AJNR Am J Neuroradiol Date: 2006-02 Impact factor: 3.825
Authors: K-O Lövblad; N Anzalone; A Dörfler; M Essig; B Hurwitz; L Kappos; S-K Lee; M Filippi Journal: AJNR Am J Neuroradiol Date: 2009-12-17 Impact factor: 3.825
Authors: J I O'Riordan; N A Losseff; C Phatouros; A J Thompson; I F Moseley; D G MacManus; W I McDonald; D H Miller Journal: J Neurol Neurosurg Psychiatry Date: 1998-03 Impact factor: 10.154
Authors: Kevin C Ma; James R Fernandez; Lilyana Amezcua; Alex Lerner; Mark S Shiroishi; Brent J Liu Journal: Comput Med Imaging Graph Date: 2015-10-23 Impact factor: 4.790