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Literature DB >> 7719637

Polyoma virus middle T antigen: meddler or mimic?

Abstract

Polyoma virus middle T antigen duplicates the actions of growth-factor receptors in binding the signalling molecules phosphatidylinositol 3'-OH kinase and Shc. These properties indicate that middle T is mitogenic and may be required to overcome inhibition of DNA replication during the lytic life cycle of the virus.

Entities: Disease Gene

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Year: 1995 PMID： 7719637 DOI： 10.1016/s0966-842x(00)88866-6

Source DB: PubMed Journal: Trends Microbiol ISSN： 0966-842X Impact factor: 17.079

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Cited

15 in total

1. ShcA tyrosine phosphorylation sites can replace ShcA binding in signalling by middle T-antigen.

Authors: P R Nicholson; S Empereur; H R Glover; S M Dilworth
Journal: EMBO J Date: 2001-11-15 Impact factor: 11.598

2. The polyomavirus middle T-antigen oncogene activates the Hippo pathway tumor suppressor Lats in a Src-dependent manner.

Authors: M Shanzer; I Ricardo-Lax; R Keshet; N Reuven; Y Shaul
Journal: Oncogene Date: 2014-11-03 Impact factor: 9.867

9. Catalytically inactive protein phosphatase 2A can bind to polyomavirus middle tumor antigen and support complex formation with pp60(c-src).

Authors: E Ogris; I Mudrak; E Mak; D Gibson; D C Pallas
Journal: J Virol Date: 1999-09 Impact factor: 5.103

Review 10. The hamster polyomavirus--a brief review of recent knowledge.

Authors: S Scherneck; R Ulrich; J Feunteun
Journal: Virus Genes Date: 2001-01 Impact factor: 2.332

Polyoma virus middle T antigen: meddler or mimic?

1. ShcA tyrosine phosphorylation sites can replace ShcA binding in signalling by middle T-antigen.

2. The polyomavirus middle T-antigen oncogene activates the Hippo pathway tumor suppressor Lats in a Src-dependent manner.

3. Effect on polyomavirus T-antigen function of mutations in a conserved leucine-rich segment of the DnaJ domain.

Review 4. Lessons in signaling and tumorigenesis from polyomavirus middle T antigen.

5. pp60c-src binding to polyomavirus middle T-antigen (MT) requires residues 185 to 210 of the MT sequence.

6. Multimerization of polyomavirus middle-T antigen.

7. A novel 39-kilodalton membrane protein binds GTP in polyomavirus-transformed cells.

8. Cytoplasmic death signal triggered by SRC-mediated phosphorylation of the adenovirus E4orf4 protein.

9. Catalytically inactive protein phosphatase 2A can bind to polyomavirus middle tumor antigen and support complex formation with pp60(c-src).

Review 10. The hamster polyomavirus--a brief review of recent knowledge.