Literature DB >> 7719410

Elevation of ratio of urinary N-acetylneuraminlactose to free sialic acid in some advanced cancer patients.

I Shimada1, M Shoji, R Futatsuya, T Katoh, Y Kominato, T Sakamoto, T Fujikura.   

Abstract

We estimated the levels of free sialic acid and sialylated oligosaccharides excreted in the urine of normal donors (n = 10) and patients with gastric cancer (n = 6) and colorectal cancer (n = 4). The total sialic acid level in cancer patients was similar to that in normal donors. However, the ratios of glycosidically bound sialic acids to free sialic acid were higher in some advanced cancer patients than in the normal donors. A major component of sialylated oligosaccharides was N-acetylneuraminyl alpha (2-->3) lactose. The elevation of the urinary ratio of this sialylated oligosaccharide to free sialic acid observed in some advanced cancer patients in this study may reflect the elevation of sialyltransferase activity in tumor tissues.

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Year:  1995        PMID： 7719410     DOI： 10.1007/bf01211370

Source DB:  PubMed          Journal:  J Gastroenterol        ISSN： 0944-1174            Impact factor:   7.527


  20 in total

1.  A RAPID PERMETHYLATION OF GLYCOLIPID, AND POLYSACCHARIDE CATALYZED BY METHYLSULFINYL CARBANION IN DIMETHYL SULFOXIDE.

Authors:  S HAKOMORI
Journal:  J Biochem       Date:  1964-02       Impact factor: 3.387

2.  Structures and serological activities of three oligosaccharides isolated from urines of nonstarved secretors and from secretors on lactose diet.

Authors:  A Lundblad; P Hallgren; A Rudmark; S Svensson
Journal:  Biochemistry       Date:  1973-08-14       Impact factor: 3.162

Review 3.  Urinary amino acid glycosides and oligosaccharides in health and disease.

Authors:  A Lundblad
Journal:  Scand J Clin Lab Invest Suppl       Date:  1980

4.  A carbohydrate domain common to both sialyl Le(a) and sialyl Le(X) is recognized by the endothelial cell leukocyte adhesion molecule ELAM-1.

Authors:  E L Berg; M K Robinson; O Mansson; E C Butcher; J L Magnani
Journal:  J Biol Chem       Date:  1991-08-15       Impact factor: 5.157

5.  Characterization of sialosylated Lewisx as a new tumor-associated antigen.

Authors:  K Fukushima; M Hirota; P I Terasaki; A Wakisaka; H Togashi; D Chia; N Suyama; Y Fukushi; E Nudelman; S Hakomori
Journal:  Cancer Res       Date:  1984-11       Impact factor: 12.701

6.  New chromatographic system for the rapid analysis and preparation of colostrum sialyloligosaccharides.

Authors:  R W Veh; J C Michalski; A P Corfield; M Sander-Wewer; D Gies; R Schauer
Journal:  J Chromatogr       Date:  1981-08-07

7.  A monoclonal antibody-defined antigen associated with gastrointestinal cancer is a ganglioside containing sialylated lacto-N-fucopentaose II.

Authors:  J L Magnani; B Nilsson; M Brockhaus; D Zopf; Z Steplewski; H Koprowski; V Ginsburg
Journal:  J Biol Chem       Date:  1982-12-10       Impact factor: 5.157

8.  Gastrointestinal cancer-associated antigen in immunoperoxidase assay.

Authors:  B F Atkinson; C S Ernst; M Herlyn; Z Steplewski; H F Sears; H Koprowski
Journal:  Cancer Res       Date:  1982-11       Impact factor: 12.701

9.  Serum sialic acid elevations in malignant melanoma patients.

Authors:  H K Silver; D M Rangel; D L Morton
Journal:  Cancer       Date:  1978-04       Impact factor: 6.860

10.  DEMONSTRATION OF TUMOR-SPECIFIC ANTIGENS IN HUMAN COLONIC CARCINOMATA BY IMMUNOLOGICAL TOLERANCE AND ABSORPTION TECHNIQUES.

Authors:  P GOLD; S O FREEDMAN
Journal:  J Exp Med       Date:  1965-03-01       Impact factor: 14.307
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  5 in total

1.  Clinical usefulness of alterations in sialic acid, sialyl transferase and sialoproteins in breast cancer.

Authors:  G N Raval; L J Parekh; D D Patel; F P Jha; R N Sainger; P S Patel
Journal:  Indian J Clin Biochem       Date:  2004-07

2.  Identification of aberrantly expressed glycans in gastric cancer by integrated lectin microarray and mass spectrometric analyses.

Authors:  Xiang Li; Feng Guan; Dongliang Li; Zengqi Tan; Ganglong Yang; Yanli Wu; Zhaohui Huang
Journal:  Oncotarget       Date:  2016-12-27

3.  Investigation of acidic free-glycans in urine and their alteration in cancer.

Authors:  Ken Hanzawa; Miki Tanaka-Okamoto; Hiroko Murakami; Mikio Mukai; Hidenori Takahashi; Takeshi Omori; Kenji Ikezawa; Kazuyoshi Ohkawa; Masayuki Ohue; Yasuhide Miyamoto
Journal:  Glycobiology       Date:  2021-05-03       Impact factor: 4.313

4.  Increased levels of acidic free-N-glycans, including multi-antennary and fucosylated structures, in the urine of cancer patients.

Authors:  Ken Hanzawa; Miki Tanaka-Okamoto; Hiroko Murakami; Noriko Suzuki; Mikio Mukai; Hidenori Takahashi; Takeshi Omori; Kenji Ikezawa; Kazuyoshi Ohkawa; Masayuki Ohue; Shunji Natsuka; Yasuhide Miyamoto
Journal:  PLoS One       Date:  2022-04-12       Impact factor: 3.240

Review 5.  Anti-Angiogenic Property of Free Human Oligosaccharides.

Authors:  Boram Bae; Haeun Kim; Hyerin Park; Young Jun Koh; Sung-Jin Bae; Ki-Tae Ha
Journal:  Biomolecules       Date:  2021-05-21
  5 in total

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