BACKGROUND:From 1980 to 1987, 849 patients with clinically resectable rectal adenocarcinoma were randomized into a controlled clinical trial to evaluate the role of preoperative radiotherapy. METHODS: Patients were given either 25 Gy during 5 to 7 days before surgery or underwent surgery alone. RESULTS: At a median follow-up time of 107 months (range, 62-144 months) the incidence of pelvic recurrence among 684 "curatively" operated patients was significantly lower among those who also received radiotherapy (P < 0.001) in all Dukes' stages. No significant difference was observed between the treatment groups with regard to frequency of distant metastases or overall survival. The time to local recurrence or distant metastasis and survival was significantly prolonged in the irradiated group. However, the postoperative mortality was 8% in the radiotherapy group compared with 2% in the surgery only group (P = 0.01). CONCLUSIONS:Preoperative short term radiotherapy reduced the incidence of pelvic recurrences and prolonged survival related to rectal cancer compared with surgery alone. The postoperative morbidity was significantly higher in the irradiated group.
RCT Entities:
BACKGROUND: From 1980 to 1987, 849 patients with clinically resectable rectal adenocarcinoma were randomized into a controlled clinical trial to evaluate the role of preoperative radiotherapy. METHODS:Patients were given either 25 Gy during 5 to 7 days before surgery or underwent surgery alone. RESULTS: At a median follow-up time of 107 months (range, 62-144 months) the incidence of pelvic recurrence among 684 "curatively" operated patients was significantly lower among those who also received radiotherapy (P < 0.001) in all Dukes' stages. No significant difference was observed between the treatment groups with regard to frequency of distant metastases or overall survival. The time to local recurrence or distant metastasis and survival was significantly prolonged in the irradiated group. However, the postoperative mortality was 8% in the radiotherapy group compared with 2% in the surgery only group (P = 0.01). CONCLUSIONS: Preoperative short term radiotherapy reduced the incidence of pelvic recurrences and prolonged survival related to rectal cancer compared with surgery alone. The postoperative morbidity was significantly higher in the irradiated group.
Authors: Giancarlo D'Ambrosio; Alessandro M Paganini; Andrea Balla; Silvia Quaresima; Pietro Ursi; Paolo Bruzzone; Andrea Picchetto; Fabrizio I Mattei; Emanuele Lezoche Journal: Surg Endosc Date: 2015-06-05 Impact factor: 4.584
Authors: G Valero; J A Luján; Q Hernández; M De Las Heras; E Pellicer; A Serrano; P Parrilla Journal: Int J Colorectal Dis Date: 2003-07-15 Impact factor: 2.571
Authors: Juan C Gutierrez; Noor Kassira; Rabih M Salloum; Dido Franceschi; Leonidas G Koniaris Journal: J Gastrointest Surg Date: 2007-09-18 Impact factor: 3.452
Authors: J Gallego-Plazas; F Menárguez-Pina; A Maestre-Peiró; V González-Orozco; F Andreu; M J Escudero-Barea; M A Morcillo Journal: Clin Transl Oncol Date: 2009-03 Impact factor: 3.405
Authors: Young Ju Noh; Won Sik Choi; Jong Hoon Kim; Jin Cheon Kim; Chang Sik Yu; Hee Cheol Kim; Tae Won Kim; Heung Moon Chang; Min Hee Ryu; Seung Do Ahn; Sang-wook Lee; Seong Soo Shin; Jung Eun Lee; Eun Kyung Choi Journal: Cancer Res Treat Date: 2006-02-28 Impact factor: 4.679