Literature DB >> 7708711

A random-walk/giant-loop model for interphase chromosomes.

R K Sachs1, G van den Engh, B Trask, H Yokota, J E Hearst.   

Abstract

Fluorescence in situ hybridization data on distances between defined genomic sequences are used to construct a quantitative model for the overall geometric structure of a human chromosome. We suggest that the large-scale geometry during the G0/G1 part of the cell cycle may consist of flexible chromatin loops, averaging approximately 3 million bp, with a random-walk backbone. A fully explicit, three-parametric polymer model of this random-walk/giant-loop structure can account well for the data. More general models consistent with the data are briefly discussed.

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Year:  1995        PMID： 7708711      PMCID： PMC42288          DOI： 10.1073/pnas.92.7.2710

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  8 in total

1.  Estimating genomic distance from DNA sequence location in cell nuclei by a random walk model.

Authors:  G van den Engh; R Sachs; B J Trask
Journal:  Science       Date:  1992-09-04       Impact factor: 47.728

2.  The ratio of dicentrics to centric rings produced in human lymphocytes by acute low-LET radiation.

Authors:  L R Hlatky; R K Sachs; P Hahnfeldt
Journal:  Radiat Res       Date:  1992-03       Impact factor: 2.841

3.  The metaphase scaffold is helically folded: sister chromatids have predominantly opposite helical handedness.

Authors:  E Boy de la Tour; U K Laemmli
Journal:  Cell       Date:  1988-12-23       Impact factor: 41.582

4.  Delineation of individual human chromosomes in metaphase and interphase cells by in situ suppression hybridization using recombinant DNA libraries.

Authors:  P Lichter; T Cremer; J Borden; L Manuelidis; D C Ward
Journal:  Hum Genet       Date:  1988-11       Impact factor: 4.132

Review 5.  Interchange and intra-nuclear architecture.

Authors:  J R Savage
Journal:  Environ Mol Mutagen       Date:  1993       Impact factor: 3.216

6.  Polymer models for interphase chromosomes.

Authors:  P Hahnfeldt; J E Hearst; D J Brenner; R K Sachs; L R Hlatky
Journal:  Proc Natl Acad Sci U S A       Date:  1993-08-15       Impact factor: 11.205

7.  Chromosomal "fingerprints" of prior exposure to densely ionizing radiation.

Authors:  D J Brenner; R K Sachs
Journal:  Radiat Res       Date:  1994-10       Impact factor: 2.841

8.  The 30 nm chromatin fiber as a flexible polymer.

Authors:  J Y Ostashevsky; C S Lange
Journal:  J Biomol Struct Dyn       Date:  1994-02
  8 in total
  100 in total

1.  Size-dependent positioning of human chromosomes in interphase nuclei.

Authors:  H B Sun; J Shen; H Yokota
Journal:  Biophys J       Date:  2000-07       Impact factor: 4.033

2.  Chromosomal G-dark bands determine the spatial organization of centromeric heterochromatin in the nucleus.

Authors:  C Carvalho; H M Pereira; J Ferreira; C Pina; D Mendonça; A C Rosa; M Carmo-Fonseca
Journal:  Mol Biol Cell       Date:  2001-11       Impact factor: 4.138

3.  The fractal globule as a model of chromatin architecture in the cell.

Authors:  Leonid A Mirny
Journal:  Chromosome Res       Date:  2011-01       Impact factor: 5.239

4.  Topography of genetic loci in the nuclei of cells of colorectal carcinoma and adjacent tissue of colonic epithelium.

Authors:  Emilie Lukásová; Stanislav Kozubek; Martin Falk; Michal Kozubek; Jan Zaloudík; Václav Vagunda; Zdenek Pavlovský
Journal:  Chromosoma       Date:  2004-01-13       Impact factor: 4.316

5.  The 3D structure of human chromosomes in cell nuclei.

Authors:  E Lukásová; S Kozubek; M Kozubek; M Falk; J Amrichová
Journal:  Chromosome Res       Date:  2002       Impact factor: 5.239

6.  Long-range interphase chromosome organization in Drosophila: a study using color barcoded fluorescence in situ hybridization and structural clustering analysis.

Authors:  Michael G Lowenstein; Thomas D Goddard; John W Sedat
Journal:  Mol Biol Cell       Date:  2004-09-15       Impact factor: 4.138

7.  Long-range compaction and flexibility of interphase chromatin in budding yeast analyzed by high-resolution imaging techniques.

Authors:  Kerstin Bystricky; Patrick Heun; Lutz Gehlen; Jörg Langowski; Susan M Gasser
Journal:  Proc Natl Acad Sci U S A       Date:  2004-11-15       Impact factor: 11.205

8.  Localization microscopy reveals expression-dependent parameters of chromatin nanostructure.

Authors:  Manfred Bohn; Philipp Diesinger; Rainer Kaufmann; Yanina Weiland; Patrick Müller; Manuel Gunkel; Alexa von Ketteler; Paul Lemmer; Michael Hausmann; Dieter W Heermann; Christoph Cremer
Journal:  Biophys J       Date:  2010-09-08       Impact factor: 4.033

9.  Modeling of chromosome intermingling by partially overlapping uniform random polygons.

Authors:  T Blackstone; R Scharein; B Borgo; R Varela; Y Diao; J Arsuaga
Journal:  J Math Biol       Date:  2010-04-09       Impact factor: 2.259

10.  Spatially confined folding of chromatin in the interphase nucleus.

Authors:  Julio Mateos-Langerak; Manfred Bohn; Wim de Leeuw; Osdilly Giromus; Erik M M Manders; Pernette J Verschure; Mireille H G Indemans; Hinco J Gierman; Dieter W Heermann; Roel van Driel; Sandra Goetze
Journal:  Proc Natl Acad Sci U S A       Date:  2009-02-20       Impact factor: 11.205
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