Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Aqueous extracts of cigarette tar containing the tar free radical cause DNA nicks in mammalian cells.

Literature DB >> 7705294

Aqueous extracts of cigarette tar containing the tar free radical cause DNA nicks in mammalian cells.

Abstract

The ability of aqueous extracts of cigarette tar to nick DNA was investigated using viable mammalian cells. Tar extracts contain a radical with a stable electron spin resonance (ESR) signal at g = 2.0036 characteristic of a semiquinone. The association of the tar component that carries the ESR signal with DNA was demonstrated using viable rat alveolar macrophages. The formation of single-strand DNA breaks caused by cigarette tar extracts in viable rat thymocytes follows saturation kinetics, indicating a tar component associates with DNA and then nicks it. These studies support our hypothesis that tar components that contain the cigarette tar radical can enter cells, associate with, and then nick DNA.

Entities: Chemical Species

Mesh：

Substances：

Year: 1994 PMID： 7705294 PMCID： PMC1566999 DOI： 10.1289/ehp.94102s10173

Source DB: PubMed Journal: Environ Health Perspect ISSN： 0091-6765 Impact factor: 9.031

26 in total

1. Cigarette smoke induces DNA single-strand breaks in human cells.

Authors: T Nakayama; M Kaneko; M Kodama; C Nagata
Journal: Nature Date: 1985 Apr 4-10 Impact factor: 49.962

2. Altered oxidative metabolic responses in vitro of alveolar macrophages from asymptomatic cigarette smokers.

Authors: J R Hoidal; R B Fox; P A LeMarbe; R Perri; J E Repine
Journal: Am Rev Respir Dis Date: 1981-01

3. DNA damage induced by cigarette smoke condensate in vitro as assayed by 32P-postlabeling. Comparison with cigarette smoke-associated DNA adduct profiles in vivo.

Authors: E Randerath; T F Danna; K Randerath
Journal: Mutat Res Date: 1992-07 Impact factor: 2.433

4. Extracellular release of hydrogen peroxide by human alveolar macrophages: the relationship to cigarette smoking and lower respiratory tract infections.

Authors: A P Greening; D B Lowrie
Journal: Clin Sci (Lond) Date: 1983-12 Impact factor: 6.124

5. Polycyclic aromatic hydrocarbon (PAH) ortho-quinone conjugate chemistry: kinetics of thiol addition to PAH ortho-quinones and structures of thioether adducts of naphthalene-1,2-dione.

Authors: V S Murty; T M Penning
Journal: Chem Biol Interact Date: 1992-09-28 Impact factor: 5.192

6. The metal-mediated formation of hydroxyl radical by aqueous extracts of cigarette tar.

Authors: J P Cosgrove; E T Borish; D F Church; W A Pryor
Journal: Biochem Biophys Res Commun Date: 1985-10-15 Impact factor: 3.575

Review 7. Glutathione-dependent toxicity.

Authors: M W Anders; W Dekant; S Vamvakas
Journal: Xenobiotica Date: 1992 Sep-Oct Impact factor: 1.908

8. The radicals in cigarette tar: their nature and suggested physiological implications.

Authors: W A Pryor; B J Hales; P I Premovic; D F Church
Journal: Science Date: 1983-04-22 Impact factor: 47.728

9. Cigarette smoking decreases bioactive interleukin-6 secretion by alveolar macrophages.

Authors: D M Soliman; H L Twigg
Journal: Am J Physiol Date: 1992-10

Review 10. Oxidants in cigarette smoke. Radicals, hydrogen peroxide, peroxynitrate, and peroxynitrite.

Authors: W A Pryor; K Stone
Journal: Ann N Y Acad Sci Date: 1993-05-28 Impact factor: 5.691

16 in total

1. Stress induction of Bm1 RNA in silkworm larvae: SINEs, an unusual class of stress genes.

Authors: R H Kimura; P V Choudary; K K Stone; C W Schmid
Journal: Cell Stress Chaperones Date: 2001-07 Impact factor: 3.667

2. DNA single strand breakage, DNA adducts, and sister chromatid exchange in lymphocytes and phenanthrene and pyrene metabolites in urine of coke oven workers.

Authors: W Popp; C Vahrenholz; C Schell; G Grimmer; G Dettbarn; R Kraus; A Brauksiepe; B Schmeling; T Gutzeit; J von Bülow; K Norpoth
Journal: Occup Environ Med Date: 1997-03 Impact factor: 4.402

3. Effects of (-)-epigallocatechin gallate (EGCG) on DNA strand breaks as evaluated by single-cell gel electrophoresis (SCG) in human lymphocytes.

Authors: L Yuquan; T Takeshita; K Morimoto
Journal: Environ Health Prev Med Date: 2001-01 Impact factor: 3.674

4. Environmental health hazards of e-cigarettes and their components: Oxidants and copper in e-cigarette aerosols.

Authors: Chad A Lerner; Isaac K Sundar; Richard M Watson; Alison Elder; Ryan Jones; Douglas Done; Rachel Kurtzman; Deborah J Ossip; Risa Robinson; Scott McIntosh; Irfan Rahman
Journal: Environ Pollut Date: 2015-01-09 Impact factor: 8.071

5. Coordinate control of expression of Nrf2-modulated genes in the human small airway epithelium is highly responsive to cigarette smoking.

Authors: Ralf-Harto Hübner; Jamie D Schwartz; P De Bishnu; Barbara Ferris; Larsson Omberg; Jason G Mezey; Neil R Hackett; Ronald G Crystal
Journal: Mol Med Date: 2009-03-20 Impact factor: 6.354

9. Tobacco smoke: involvement of reactive oxygen species and stable free radicals in mechanisms of oxidative damage, carcinogenesis and synergistic effects with other respirable particles.

Authors: Athanasios Valavanidis; Thomais Vlachogianni; Konstantinos Fiotakis
Journal: Int J Environ Res Public Health Date: 2009-02-02 Impact factor: 3.390

10. Oxidative stress, cell death, and other damage to alveolar epithelial cells induced by cigarette smoke.

Authors: K Aoshiba; A Nagai
Journal: Tob Induc Dis Date: 2003-09-15 Impact factor: 2.600