Literature DB >> 7703397

Glial cell line-derived neurotrophic factor (GDNF), a new neurotrophic factor for motoneurones.

A D Zurn1, E E Baetge, J P Hammang, S A Tan, P Aebischer.   

Abstract

Glial cell line-derived neurotrophic factor (GDNF) has been postulated to be a specific dopaminergic neurotrophic factor since it selectively enhances the survival of dopaminergic neurones in vitro. We report here that GDNF can also act as a neurotrophic factor for motoneurones. GDNF released by GDNF-transfected BHK cells increases the activity of choline acetyltransferase (ChAT) in cultures from embryonic rat ventral mesencephalon containing cholinergic neurones from cranial motor nuclei and in cultured spinal motoneurones. Furthermore, local application of polymer-encapsulated BHK cells releasing GDNF to transected facial nerve in newborn rats diminishes the death of motoneurones normally occurring after axotomy in the neonatal period. The present results indicate that GDNF may have a therapeutic potential in human motoneurone diseases such as amyotrophic lateral sclerosis.

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Year:  1994        PMID： 7703397     DOI： 10.1097/00001756-199412300-00030

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  15 in total

Review 1.  Molecular mechanisms regulating motor neuron development and degeneration.

Authors:  T J Kilpatrick; M Soilu-Hänninen
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2.  Endogenous ciliary neurotrophic factor is a lesion factor for axotomized motoneurons in adult mice.

Authors:  M Sendtner; R Götz; B Holtmann; H Thoenen
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Review 3.  The involvement of BDNF, NGF and GDNF in aging and Alzheimer's disease.

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Review 4.  Acetylcholine release and the cholinergic genomic locus.

Authors:  M Israël; Y Dunant
Journal:  Mol Neurobiol       Date:  1998-02       Impact factor: 5.590

5.  GFRalpha3 is an orphan member of the GDNF/neurturin/persephin receptor family.

Authors:  R H Baloh; A Gorodinsky; J P Golden; M G Tansey; C L Keck; N C Popescu; E M Johnson; J Milbrandt
Journal:  Proc Natl Acad Sci U S A       Date:  1998-05-12       Impact factor: 11.205

6.  Complete and long-term rescue of lesioned adult motoneurons by lentiviral-mediated expression of glial cell line-derived neurotrophic factor in the facial nucleus.

Authors:  A F Hottinger; M Azzouz; N Déglon; P Aebischer; A D Zurn
Journal:  J Neurosci       Date:  2000-08-01       Impact factor: 6.167

7.  Disruption of calcitonin gene-related peptide signaling accelerates muscle denervation and dampens cytotoxic neuroinflammation in SOD1 mutant mice.

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8.  GDNF reduces drug-induced rotational behavior after medial forebrain bundle transection by a mechanism not involving striatal dopamine.

Authors:  J L Tseng; E E Baetge; A D Zurn; P Aebischer
Journal:  J Neurosci       Date:  1997-01-01       Impact factor: 6.167

9.  Short-term exercise increases GDNF protein levels in the spinal cord of young and old rats.

Authors:  M J McCullough; A M Gyorkos; J M Spitsbergen
Journal:  Neuroscience       Date:  2013-03-14       Impact factor: 3.590

10.  Retrograde axonal transport of glial cell line-derived neurotrophic factor in the adult nigrostriatal system suggests a trophic role in the adult.

Authors:  A Tomac; J Widenfalk; L F Lin; T Kohno; T Ebendal; B J Hoffer; L Olson
Journal:  Proc Natl Acad Sci U S A       Date:  1995-08-29       Impact factor: 11.205
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