Literature DB >> 26425388

The involvement of BDNF, NGF and GDNF in aging and Alzheimer's disease.

Josiane Budni1, Tatiani Bellettini-Santos1, Francielle Mina1, Michelle Lima Garcez1, Alexandra Ioppi Zugno1.   

Abstract

Aging is a normal physiological process accompanied by cognitive decline. This aging process has been the primary risk factor for development of aging-related diseases such as Alzheimer's disease (AD). Cognitive deficit is related to alterations of neurotrophic factors level such as brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF) and glial cell-derived neurotrophic factor (GDNF). These strong relationship between aging and AD is important to investigate the time which they overlap, as well as, the pathophysiological mechanism in each event. Considering that aging and AD are related to cognitive impairment, here we discuss the involving these neurotrophic factors in the aging process and AD.

Entities:  

Keywords:  Aging; Alzheimer’s disease; BNDF; GDNF; NGF

Year:  2015        PMID： 26425388      PMCID： PMC4567216          DOI： 10.14336/AD.2015.0825

Source DB:  PubMed          Journal:  Aging Dis        ISSN： 2152-5250            Impact factor:   6.745


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