Literature DB >> 7701560

The macroworld versus the microworld of biochemical regulation and control.

B N Kholodenko1, H V Westerhoff.   

Abstract

Our understanding of cell physiology has been helped greatly by viewing metabolism as a set of reactions catalysed by independent catalysts (enzymes) in ideal solutions. Yet the differences between this idealized cell and reality have strong implications for biochemical regulation and control. We show here that in the real cell an enzyme controls cell physiology in more than a single way. These different controlling modes in the real 'macroworld' can be related to one another by implementing a new type of control analysis, which is formulated in terms of the 'microworld' of the elemental processes.

Mesh：

Year:  1995        PMID： 7701560     DOI： 10.1016/s0968-0004(00)88955-0

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  18 in total

1.  Properties of switch-like bioregulatory networks studied by simulation of the hypoxia response control system.

Authors:  Kurt W Kohn; Joseph Riss; Olga Aprelikova; John N Weinstein; Yves Pommier; J Carl Barrett
Journal:  Mol Biol Cell       Date:  2004-04-23       Impact factor: 4.138

2.  Evolution of dominance in metabolic pathways.

Authors:  Homayoun C Bagheri; Günter P Wagner
Journal:  Genetics       Date:  2004-11       Impact factor: 4.562

3.  Molecular interaction maps of bioregulatory networks: a general rubric for systems biology.

Authors:  Kurt W Kohn; Mirit I Aladjem; John N Weinstein; Yves Pommier
Journal:  Mol Biol Cell       Date:  2005-11-02       Impact factor: 4.138

4.  Understanding bistability in complex enzyme-driven reaction networks.

Authors:  Gheorghe Craciun; Yangzhong Tang; Martin Feinberg
Journal:  Proc Natl Acad Sci U S A       Date:  2006-05-30       Impact factor: 11.205

5.  A minimal and self-consistent in silico cell model based on macromolecular interactions.

Authors:  Christoph Flamm; Lukas Endler; Stefan Müller; Stefanie Widder; Peter Schuster
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2007-10-29       Impact factor: 6.237

6.  Subtleties in control by metabolic channelling and enzyme organization.

Authors:  B N Kholodenko; J M Rohwer; M Cascante; H V Westerhoff
Journal:  Mol Cell Biochem       Date:  1998-07       Impact factor: 3.396

Review 7.  Elusive control.

Authors:  H V Westerhoff; B N Kholodenko; M Cascante; K Van Dam
Journal:  J Bioenerg Biomembr       Date:  1995-10       Impact factor: 2.945

8.  Effect of channelling on the concentration of bulk-phase intermediates as cytosolic proteins become more concentrated.

Authors:  B N Kholodenko; H V Westerhoff; M Cascante
Journal:  Biochem J       Date:  1996-02-01       Impact factor: 3.857

9.  Paradoxical control properties of enzymes within pathways: can activation cause an enzyme to have increased control?

Authors:  B N Kholodenko; G C Brown
Journal:  Biochem J       Date:  1996-03-15       Impact factor: 3.857

10.  Implications of macromolecular crowding for signal transduction and metabolite channeling.

Authors:  J M Rohwer; P W Postma; B N Kholodenko; H V Westerhoff
Journal:  Proc Natl Acad Sci U S A       Date:  1998-09-01       Impact factor: 11.205
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