Literature DB >> 7700990

Naturally occurring protein kinase C inhibitors; II. Isolation of oligomeric stilbenes from Caragana sinica.

P Kulanthaivel1, W P Janzen, L M Ballas, J B Jiang, C Q Hu, J W Darges, J C Seldin, D J Cofield, L M Adams.   

Abstract

The oligomeric stilbenes (+)-alpha-viniferin (1), miyabenol C (2), and kobophenol A (3) have been isolated from Caragana sinica (Buchoz) Rehd (Leguminosae). (+)-alpha-Viniferin (1) and miyabenol C (2) exhibited protein kinase C inhibitory activity at low micromolar concentrations. (+)-alpha-Viniferin inhibited keratinocyte proliferation (0.4 microM) and free radical release in whole blood (47 microM), in vitro, and may be useful in treating hyperproliferative or inflammatory skin diseases.

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Year:  1995        PMID： 7700990     DOI： 10.1055/s-2006-957996

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  9 in total

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Review 4.  Polyphenol compounds and PKC signaling.

Authors:  Joydip Das; Rashmi Ramani; M Olufemi Suraju
Journal:  Biochim Biophys Acta       Date:  2016-06-29

Review 5.  Resveratrol oligomers for the prevention and treatment of cancers.

Authors:  You-Qiu Xue; Jin-Ming Di; Yun Luo; Ke-Jun Cheng; Xing Wei; Zhi Shi
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6.  The resveratrol trimer miyabenol C inhibits β-secretase activity and β-amyloid generation.

Authors:  Jin Hu; Ting Lin; Yuehong Gao; Junyue Xu; Chao Jiang; Guanghui Wang; Guojun Bu; Huaxi Xu; Haifeng Chen; Yun-wu Zhang
Journal:  PLoS One       Date:  2015-01-28       Impact factor: 3.240

7.  Kobophenol A Isolated from Roots of Caragana sinica (Buc'hoz) Rehder Exhibits Anti-inflammatory Activity by Regulating NF-κB Nuclear Translocation in J774A.1 Cells.

Authors:  Hana Cho; Ju-Hyoung Park; Eun-Kyung Ahn; Joa Sub Oh
Journal:  Toxicol Rep       Date:  2018-05-19

8.  System Prediction and Validation of TCM for Chronic Myeloid Leukemia Treatment from the Perspective of Low-Toxicity Chemotherapy: A Stilbene α-Viniferin Has a Proapoptotic Effect on K562 Cells via the Mitochondrial Pathway.

Authors:  Bing-Yang Chai; Fu-Kai Gong; Ze-Hui Chen; Zhao-Xue Li; Bo Zhang
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9.  Pruinosanones A-C, anti-inflammatory isoflavone derivatives from Caragana pruinosa.

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  9 in total

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